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1. WO2021010812 - SYNERGISTIC COMBINATION OF S-KETOROLAC AND PREGABALIN IN A PHARMACEUTICAL COMPOSITION FOR THE TREATMENT OF NEUROPATHIC PAIN

Publication Number WO/2021/010812
Publication Date 21.01.2021
International Application No. PCT/MX2020/050011
International Filing Date 11.06.2020
IPC
A61K 31/14 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
13Amines, e.g. amantadine
14Quaternary ammonium compounds, e.g. edrophonium, choline
A61K 31/407 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
40having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
407condensed with heterocyclic ring systems, e.g. ketorolac, physostigmine
A61P 25/08 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
08Antiepileptics; Anticonvulsants
A61P 29/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
29Non-central analgesic, antipyretic or antiinflammatory agents, e.g antirheumatic agents; Non-steroidal antiinflammatory drugs (NSAIDs)
CPC
A61K 31/14
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
13Amines
14Quaternary ammonium compounds, e.g. edrophonium, choline
A61K 31/197
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic, hydroximic acids
19Carboxylic acids, e.g. valproic acid
195having an amino group
197the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid, pantothenic acid
A61K 31/407
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
40having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
407condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
A61P 25/08
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
08Antiepileptics; Anticonvulsants
A61P 29/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
29Non-central analgesic, antipyretic or anti-inflammatory agents, e.g antirheumatic agents; Non-steroidal anti-inflammatory drugs (NSAIDs)
Applicants
  • AMEZCUA AMEZCUA, Federico [MX]/[MX]
  • AMEZCUA AMEZCUA, Carlos [MX]/[MX]
Inventors
  • GARCIA ARMENTA, Patricia del Carmen
  • CHAVEZ GARCÍA, Jose Alonso
Agents
  • RENDÓN, Aida
Priority Data
MX/a/2019/00846716.07.2019MX
Publication Language Spanish (ES)
Filing Language Spanish (ES)
Designated States
Title
(EN) SYNERGISTIC COMBINATION OF S-KETOROLAC AND PREGABALIN IN A PHARMACEUTICAL COMPOSITION FOR THE TREATMENT OF NEUROPATHIC PAIN
(ES) COMBINACIÓN SINÉRGICA DE S-KETOROLACO Y PREGABALINA EN UNA COMPOSICIÓN FARMACÉUTICA PARA EL TRATAMIENTO DEL DOLOR NEUROPÁTICO.
(FR) COMBINAISON SYNERGIQUE DE S-KÉTOROLAC ET PRÉGABALINE DANS UNE COMPOSITION PHARMACEUTIQUE POUR LE TRAITEMENT DE LA DOULEUR NEUROPATHIQUE
Abstract
(EN)
The present invention relates to the synergistic combination of a non-steroidal anti-inflammatory analgaesic, such as ketorolac or its isomer S-ketorolac or pharmaceutically acceptable salts thereof, and an analogue agent of the neurotransmitter gamma aminobutyric acid (GABA) from the neuromodulator group, such as the active ingredient pregabalin or a pharmaceutically acceptable salt of same, wherein said combination is useful for formulation in a pharmaceutical composition for oral administration, suitable for the treatment of neuropathic pain in patients with recurrent neuropathic pain or in post-surgical patients, as well as in analgaesic and anti-inflammatory therapy.
(ES)
La presente invención está relacionada con la combinación sinérgica de un analgésico antiinflamatorio no esteroideo como lo es el ketorolaco o su isómero S-Ketorolaco o sus sales farmacéuticamente aceptables y un agente análogo del neurotransmisor ácido gammaminobutírico (GABA) del grupo de los neuromoduladores, como lo es el principio activo pregabalina o una sal farmacéuticamente aceptable de la misma, donde dicha combinación es útil para ser formulada en una composición farmacéutica para ser administrada por vía oral, indicada para el tratamiento del dolor neuropático en pacientes con dicho dolor recurrente o en pacientes postquirúrgicos, así como en la terapia analgésica y antiinflamatoria.
(FR)
La présente invention concerne la combinaison synergique d'un analgésique anti-inflammatoire non stéroïdien de type kétorolac ou son isomère S-kétorolac ou leurs sels pharmaceutiquement acceptables et d'un agent analogue du neurotransmetteur acide gamma-aminobutyrique (GABA) du groupe des neuromodulateurs, comme le principe actif prégabaline ou un sel pharmaceutiquement acceptable de celle-ci, ladite combinaison étant utile pour être formulée dans une composition pharmaceutique en vue d'une administration par voie orale, indiquée pour le traitement de la douleur neuropathique chez des patients souffrant de douleur récurrente ou chez les patients post-opératoires, ainsi qu'en thérapie analgésique et anti-inflammatoire.
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