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1. WO2021010698 - CANCER CELL-TARGETED DRUG DELIVERY CARRIER AND COMPOSITION FOR PROMOTING PHOTO-THERMAL TREATMENT EFFECTS, BOTH OF WHICH CONTAIN M1 MACROPHAGES AS ACTIVE INGREDIENT

Publication Number WO/2021/010698
Publication Date 21.01.2021
International Application No. PCT/KR2020/009173
International Filing Date 13.07.2020
IPC
A61K 41/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
41Medicinal preparations obtained by treating materials with wave energy or particle radiation
A61K 47/44 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
44Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42107; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
A61K 47/02 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
02Inorganic compounds
A61K 45/06 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
45Medicinal preparations containing active ingredients not provided for in groups A61K31/-A61K41/132
06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
A61P 35/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
C12N 5/0786 2010.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
5Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
07Animal cells or tissues
071Vertebrate cells or tissues, e.g. human cells or tissues
078Cells from blood or from the immune system
0786Monocytes; Macrophages
Applicants
  • 고려대학교 산학협력단 KOREA UNIVERSITY RESEARCH AND BUSINESS FOUNDATION [KR]/[KR]
Inventors
  • 백승국 BAEK, Seung Kuk
  • 임누리 IM, Nu Ri
Agents
  • 특허법인 다해 DAHAI INTERNATIONAL PATENT & LAW FIRM
Priority Data
10-2019-008466512.07.2019KR
Publication Language Korean (KO)
Filing Language Korean (KO)
Designated States
Title
(EN) CANCER CELL-TARGETED DRUG DELIVERY CARRIER AND COMPOSITION FOR PROMOTING PHOTO-THERMAL TREATMENT EFFECTS, BOTH OF WHICH CONTAIN M1 MACROPHAGES AS ACTIVE INGREDIENT
(FR) SUPPORT D'ADMINISTRATION DE MÉDICAMENT CIBLANT DES CELLULES CANCÉREUSES ET COMPOSITION POUR FAVORISER DES EFFETS DE TRAITEMENT PHOTO-THERMIQUE, LES DEUX CONTENANT DES MACROPHAGES M1 EN TANT QUE PRINCIPE ACTIF
(KO) M1 대식세포를 유효성분으로 포함하는 암세포 표적형 약물 전달체 및 광열치료 효과 증진용 조성물
Abstract
(EN)
The present invention relates to a cancer cell-targeted drug delivery carrier, a composition for promoting photo-thermal treatment effects, and the like, which contain M1 macrophages as an active ingredient. The drug delivery carrier of the present invention uses the M1 macrophage mobility to tumor cells and the M1 macrophage penetrability into tumors, and can deliver drugs specifically to tumor and cancer tissues only, and, when performing photo-thermal treatment by loading M1 macrophages with a photosensitive material, can significantly increase the effects, and thus is expected to be effectively used for promoting cancer treatment effects.
(FR)
La présente invention concerne un support d'administration de médicament ciblant des cellules cancéreuses, une composition pour favoriser des effets de traitement photo-thermique, et analogues, qui contiennent des macrophages M1 en tant que principe actif. Le vecteur d'administration de médicament de la présente invention utilise la mobilité des macrophages M1 vis-à-vis des cellules tumorales et la pénétrabilité des macrophages M1 dans les tumeurs, et permet d'administrer des médicaments spécifiquement à des tissus tumoraux et cancéreux uniquement. En outre, lors de la réalisation d'un traitement photo-thermique par chargement de macrophages M1 avec une matière photosensible, il permet d'augmenter significativement les effets, d'où sa supposée efficacité pour favoriser les effets de traitement du cancer.
(KO)
M1 대식세포를 유효성분으로 포함하는, 암세포 표적형 약물 전달체 및 광열치료 효과 증진용 조성물 등에 관한 것으로서, 본 발명의 약물 전달체는 M1 대식세포의 종양 세포로의 이동성 및 종양 내부로의 침투력을 이용한 것으로서 종양 및 암 조직에만 특이적으로 약물을 전달할 수 있으며, 상기 M1 대식세포에 광 감응물질을 로딩하여 광열치료를 수행하는 경우 그 효과를 현저하게 상승시킬 수 있는 효과가 있는 바, 암의 치료 효과를 증진시키기 위해 유용하게 이용될 것으로 기대된다.
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