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1. WO2021009640 - THERAPEUTIC POTENTIAL OF CURCUMIN/CYCLODEXTRIN/CELLULOSE NANOCRYSTALS IN THE TREATMENT OF PERIPHERAL NEUROPATHIES

Publication Number WO/2021/009640
Publication Date 21.01.2021
International Application No. PCT/IB2020/056505
International Filing Date 10.07.2020
IPC
A61K 9/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
A61K 9/06 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
06Ointments; Bases therefor
A61K 9/14 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
14Particulate form, e.g. powders
A61K 31/12 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
12Ketones
A61K 31/717 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
70Carbohydrates; Sugars; Derivatives thereof
715Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
716Glucans
717Celluloses
A61K 31/724 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
70Carbohydrates; Sugars; Derivatives thereof
715Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
716Glucans
724Cyclodextrins
CPC
A61K 2300/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
2300Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
A61K 31/12
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
12Ketones
A61K 31/717
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
70Carbohydrates; Sugars; Derivatives thereof
715Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
716Glucans
717Celluloses
A61K 31/724
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
70Carbohydrates; Sugars; Derivatives thereof
715Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
716Glucans
724Cyclodextrins
A61K 36/9066
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
36Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
18Magnoliophyta (angiosperms)
88Liliopsida (monocotyledons)
906Zingiberaceae (Ginger family)
9066Curcuma, e.g. common turmeric, East Indian arrowroot or mango ginger
A61K 9/0024
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
0012Galenical forms characterised by the site of application
0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
0024Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
Applicants
  • UNIVERSITE DE LIMOGES [FR]/[FR]
Inventors
  • CAILLAUD, Martial
  • DESMOULIÈRE, Alexis
  • BILLET, Fabrice
  • STURTZ, Franck
  • NDONG-NTOUTOUME, Gautier Marck Arthur
  • SOL, Vincent
  • GRANET, Robert
Agents
  • CABINET CHAILLOT
Priority Data
190789712.07.2019FR
Publication Language French (FR)
Filing Language French (FR)
Designated States
Title
(EN) THERAPEUTIC POTENTIAL OF CURCUMIN/CYCLODEXTRIN/CELLULOSE NANOCRYSTALS IN THE TREATMENT OF PERIPHERAL NEUROPATHIES
(FR) POTENTIEL THÉRAPEUTIQUE DES NANOCRISTAUX DE CELLULOSE-CYCLODEXTRINE-CURCUMINE DANS LE TRAITEMENT DES NEUROPATHIES PÉRIPHÉRIQUES
Abstract
(EN)
The invention relates to a complex comprising: nanocrystals of cellulose, at least one molecule of β-cyclodextrin, and at least one molecule of curcumin, for use in the treatment of all types of peripheral neuropathy. The invention also relates to a pharmaceutical composition comprising at least the complex and at least one pharmaceutically acceptable excipient. The invention further relates to the use of the complex or the pharmaceutical composition, particularly in the form of a hydrogel, subcutaneous implant, implantable pump, or implanted biofunctionalised nerve conduit, in order to improve compliance with the treatment, to allow prolonged release of the complex and to achieve better pharmacokinetics.
(FR)
L'invention concerne un complexe comprenant : des nanocristaux de cellulose; au moins une molécule de β-cyclodextrine; - au moins une molécule de curcumine, pour une utilisation dans le traitement de tout type de neuropathies périphériques. L'invention concerne également une composition pharmaceutique comprenant au moins ledit complexe et au moins un excipient pharmaceutiquement acceptable. L'invention concerne en outre l'utilisation du complexe ou de la composition pharmaceutique, sous la forme notamment d'hydrogel, d'implant sous-cutané, de pompe implantable, de conduit nerveux biofonctionnalisé implanté, pour améliorer l'observance du traitement, permettre une libération prolongée du complexe et obtenir une meilleure pharmacocinétique.
Also published as
Latest bibliographic data on file with the International Bureau