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1. WO2021009506 - FLUORESCENT SYSTEMS FOR BIOLOGICAL IMAGING AND USES THEREOF

Publication Number WO/2021/009506
Publication Date 21.01.2021
International Application No. PCT/GB2020/051694
International Filing Date 14.07.2020
IPC
C09B 23/01 2006.01
CCHEMISTRY; METALLURGY
09DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
BORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES; MORDANTS; LAKES
23Methine or polymethine dyes, e.g. cyanine dyes
01characterised by the methine chain
C09B 23/04 2006.01
CCHEMISTRY; METALLURGY
09DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
BORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES; MORDANTS; LAKES
23Methine or polymethine dyes, e.g. cyanine dyes
01characterised by the methine chain
02containing an odd number of CH groups
04one CH group, e.g. cyanines, isocyanines, pseudocyanines
C09B 23/10 2006.01
CCHEMISTRY; METALLURGY
09DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
BORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES; MORDANTS; LAKES
23Methine or polymethine dyes, e.g. cyanine dyes
01characterised by the methine chain
10containing an even number of CH groups
C09B 23/14 2006.01
CCHEMISTRY; METALLURGY
09DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
BORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES; MORDANTS; LAKES
23Methine or polymethine dyes, e.g. cyanine dyes
14Styryl dyes
G01N 33/58 2006.01
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48Biological material, e.g. blood, urine; Haemocytometers
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
58involving labelled substances
CPC
C09B 23/0075
CCHEMISTRY; METALLURGY
09DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
BORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES ; , e.g. PIGMENTS; MORDANTS; LAKES
23Methine or polymethine dyes, e.g. cyanine dyes
0075the polymethine chain being part of an heterocyclic ring
C09B 23/04
CCHEMISTRY; METALLURGY
09DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
BORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES ; , e.g. PIGMENTS; MORDANTS; LAKES
23Methine or polymethine dyes, e.g. cyanine dyes
02the polymethine chain containing an odd number of >CH- ; or >C[alkyl]-; groups
04one >CH- group, e.g. cyanines, isocyanines, pseudocyanines
C09B 23/105
CCHEMISTRY; METALLURGY
09DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
BORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES ; , e.g. PIGMENTS; MORDANTS; LAKES
23Methine or polymethine dyes, e.g. cyanine dyes
10The polymethine chain containing an even number of >CH- groups
105two >CH- groups
C09B 23/14
CCHEMISTRY; METALLURGY
09DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
BORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES ; , e.g. PIGMENTS; MORDANTS; LAKES
23Methine or polymethine dyes, e.g. cyanine dyes
14Styryl dyes
Applicants
  • LIGHTOX LIMITED [GB]/[GB]
Inventors
  • WHITING, Andrew
  • AMBLER, Carrie
  • CHISHOLM, David
Agents
  • DEFINITION IP LIMITED
Priority Data
1910239.117.07.2019GB
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) FLUORESCENT SYSTEMS FOR BIOLOGICAL IMAGING AND USES THEREOF
(FR) SYSTÈMES FLUORESCENTS POUR IMAGERIE BIOLOGIQUE ET UTILISATIONS ASSOCIÉES
Abstract
(EN)
The invention relates to compounds of formula I, in which Y, Ar1, Ar2, X, R1 and R2 are defined herein, and to their use in a variety of biological imaging techniques and therapeutic methods. In aspects, the invention relates to conjugates comprising the compounds of formula I and their associated uses and therapeutic uses.
(FR)
L'invention concerne des composés de formule I, dans laquelle Y, Ar1, Ar2, X, R1 et R2 sont tels que définis dans la description, et leur utilisation dans diverses techniques d'imagerie biologique et divers procédés thérapeutiques. Dans certains aspects, l'invention concerne des conjugués comprenant les composés de formule I et leurs utilisations correspondantes et utilisations thérapeutiques associées.
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