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1. WO2021004561 - RUBELLA VIRUS SPIKE CONSTRUCT

Publication Number WO/2021/004561
Publication Date 14.01.2021
International Application No. PCT/DE2020/000024
International Filing Date 14.02.2020
IPC
C07K 14/005 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
005from viruses
A61K 39/12 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
12Viral antigens
G01N 33/569 2006.01
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48Biological material, e.g. blood, urine; Haemocytometers
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53Immunoassay; Biospecific binding assay; Materials therefor
569for microorganisms, e.g. protozoa, bacteria, viruses
CPC
A61K 2039/5258
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
51comprising whole cells, viruses or DNA/RNA
525Virus
5258Virus-like particles
A61K 2039/627
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
62characterised by the link between antigen and carrier
627characterised by the linker
A61K 2039/70
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
70Multivalent vaccine
A61K 39/12
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
12Viral antigens
A61P 31/14
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
12Antivirals
14for RNA viruses
C07K 14/005
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
005from viruses
Applicants
  • INSTITUT VIRION-SERION GMBH WÜRZBURG [DE]/[DE]
  • STÜRMER, Judith [DE]/[DE]
Inventors
  • SCHUMACHER, Thomas
  • ARENDS, Hugo M.
Agents
  • RUDOLPH, Ulrike
Priority Data
10 2019 004 812.110.07.2019DE
Publication Language German (DE)
Filing Language German (DE)
Designated States
Title
(DE) RUBELLA VIRUS SPIKE KONSTRUKT
(EN) RUBELLA VIRUS SPIKE CONSTRUCT
(FR) STRUCTURE DE SPICULE DU VIRUS DE LA RUBÉOLE
Abstract
(DE)
Das Rubella Virus Spike Konstrukt umfasst wenigstens eine E1-Komponente und eine E2-Komponente, die miteinander verbunden sind. Die E1-Komponente besteht aus dem E1-Hüllprotein, dessen C-terminale Transmembranregion und intravirionale Domäne entfernt sind, und dessen N-Terminus die Ektodomäne des E1-Hüllproteins umfasst. Die E2-Komponente besteht aus dem E2-Hüllprotein, dessen Transmembranregionen und intravirionale Domäne entfernt sind, und dessen C-Terminus die Ektodomäne des E2-Hüllproteins umfasst. Der C-Terminus der E2-Komponente ist mit dem N-Terminus der E1-Komponente in direkter Fusion oder mittels Linker verbunden, so dass ein E1-E2-Fusionsprotein vorliegt.
(EN)
The Rubella virus spike construct comprises at least an E1 component and an E2 component that are interlinked. The E1 component consists of the E1 envelope protein whose C terminal transmembrane region and intravirion domain have been removed and whose N terminus comprises the ectodomain of the E1 envelope protein. The E2 component consists of the E2 envelope protein whose transmembrane regions and intravirion domain have been removed and whose C terminus comprises the ectodomain of the E2 envelope protein. The C terminus of the E2 component is linked by direct fusion or by means of a linker so that an E1-E2 fusion protein is obtained.
(FR)
La présente invention concerne une structure de spicule du virus de la rubéole qui comprend au moins un composant E1 et un composant E2 qui sont reliés entre eux. Le composant E1 est constitué de la protéine d'enveloppe E1 dont la région transmembranaire C-terminale et les domaines intravirionaux sont éloignés et dont l'extrémité N-terminale comprend les ectodomaines de la protéine d'enveloppe E1. Le composant E2 est constitué de la protéine d'enveloppe E2 dont les régions transmembranaires et les domaines intravirionaux sont éloignés et dont l'extrémité C-terminale comprend les ectodomaines de la protéine d'enveloppe E2. L'extrémité C-terminale du composant E2 est reliée à l'extrémité N-terminale du composant E1 par fusion directe ou au moyen de lieurs, de sorte à présenter une protéine de fusion E1-E2.
Also published as
EP2020710414
Latest bibliographic data on file with the International Bureau