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1. WO2021003129 - ENGINEERED ACETATE KINASE VARIANT ENZYMES

Publication Number WO/2021/003129
Publication Date 07.01.2021
International Application No. PCT/US2020/040244
International Filing Date 30.06.2020
IPC
C12N 9/12 2006.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
9Enzymes, e.g. ligases (6.); Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating, or purifying enzymes
10Transferases (2.)
12transferring phosphorus containing groups, e.g. kinases (2.7)
Applicants
  • CODEXIS, INC. [US]/[US]
Inventors
  • VROOM, Jonathan
  • ORTEGA GUERRA, Alberto
  • NAZOR, Jovana
  • KRAWCZYK, Mikayla, Jianghongxia
Agents
  • NEELY WILLIS, Melanie
  • MACKNIGHT, Kamrin, T.
Priority Data
62/869,66702.07.2019US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) ENGINEERED ACETATE KINASE VARIANT ENZYMES
(FR) ENZYMES VARIANTES D'ACÉTATE KINASE MODIFIÉES
Abstract
(EN)
The present invention provides engineered acetate kinase (AcK) enzymes, polypeptides having AcK activity, and polynucleotides encoding these enzymes, as well as vectors and host cells comprising these polynucleotides and polypeptides. Methods for producing AcK enzymes are also provided. The present invention further provides compositions comprising the AcK enzymes and methods of using the engineered AcK enzymes. The present invention finds particular use in the production of pharmaceutical compounds.
(FR)
La présente invention concerne des enzymes d'acétate kinase (AcK) modifiées, des polypeptides ayant une activité AcK, et des polynucléotides codant pour ces enzymes, ainsi que des vecteurs et des cellules hôtes comprenant ces polynucléotides et polypeptides. L'invention concerne également des procédés de production d'enzymes AcK. La présente invention concerne en outre des compositions comprenant les enzymes AcK et des procédés d'utilisation des enzymes AcK modifiées. La présente invention trouve une utilisation particulière dans la production de composés pharmaceutiques.
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