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1. WO2021002371 - GLYCOSYLATED PROTEIN ASSAY REAGENT CONTAINING PROTEASE STABILIZER INCREASING REDOX POTENTIAL OF FERROCYANIDE, METHOD FOR ASSAYING GLYCOSYLATED PROTEIN, METHOD FOR PRESERVING GLYCOSYLATED PROTEIN ASSAY REAGENT, AND METHOD FOR STABILIZING GLYCOSYLATED PROTEIN ASSAY REAGENT

Publication Number WO/2021/002371
Publication Date 07.01.2021
International Application No. PCT/JP2020/025738
International Filing Date 30.06.2020
IPC
C12Q 1/37 2006.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
34involving hydrolase
37involving peptidase or proteinase
C12M 1/34 2006.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY
1Apparatus for enzymology or microbiology
34Measuring or testing with condition measuring or sensing means, e.g. colony counters
C12Q 1/26 2006.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
26involving oxidoreductase
G01N 33/68 2006.01
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48Biological material, e.g. blood, urine; Haemocytometers
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
68involving proteins, peptides or amino acids
Applicants
  • 旭化成ファーマ株式会社 ASAHI KASEI PHARMA CORPORATION [JP]/[JP]
Inventors
  • 本庄 暁子 HONJO, Akiko
  • 植田 祐生 UEDA, Yuki
  • 今野 翔太 KONNO, Shota
Agents
  • 稲葉 良幸 INABA, Yoshiyuki
  • 大貫 敏史 ONUKI, Toshifumi
  • 内藤 和彦 NAITO, Kazuhiko
Priority Data
2019-12287501.07.2019JP
2019-12299701.07.2019JP
Publication Language Japanese (JA)
Filing Language Japanese (JA)
Designated States
Title
(EN) GLYCOSYLATED PROTEIN ASSAY REAGENT CONTAINING PROTEASE STABILIZER INCREASING REDOX POTENTIAL OF FERROCYANIDE, METHOD FOR ASSAYING GLYCOSYLATED PROTEIN, METHOD FOR PRESERVING GLYCOSYLATED PROTEIN ASSAY REAGENT, AND METHOD FOR STABILIZING GLYCOSYLATED PROTEIN ASSAY REAGENT
(FR) RÉACTIF DE DOSAGE DE PROTÉINE GLYCOSYLÉE CONTENANT UN STABILISANT DE PROTÉASE AUGMENTANT LE POTENTIEL REDOX DE FERROCYANURE, PROCÉDÉ DE DOSAGE DE PROTÉINE GLYCOSYLÉE, PROCÉDÉ DE CONSERVATION DE RÉACTIF DE DOSAGE DE PROTÉINE GLYCOSYLÉE, ET PROCÉDÉ DE STABILISATION DE RÉACTIF DE DOSAGE DE PROTÉINE GLYCOSYLÉE
(JA) フェロシアン化物の酸化還元電位を大きくするプロテアーゼの安定化剤を含む糖化タンパク質測定試薬、糖化タンパク質の測定方法、糖化タンパク質測定試薬の保存方法、及び糖化タンパク質測定試薬の安定化方法
Abstract
(EN)
Provided is a glycosylated protein assay reagent containing at least Trinder reagent, 4-Aminoantipyrine, a protease, a protease stabilizer, and a ferrocyanide, wherein at least the Trinder reagent is included in a Trinder reagent-containing partial composition, at least the 4-Aminoantipyrine is included in a 4-Aminoantiyrine-containing partial composition, the protease stabilizer is a stabilizer that increases the redox potential of the ferrocyanide to more than 0.058 V when the ferrocyanide is mixed with the protease stabilizer, and the redox potential is determined in a reaction system that contains the protease stabilizer and the ferrocyanide and does not contain the glycosylated protein.
(FR)
L'invention concerne un réactif de dosage de protéine glycosylée contenant au moins un réactif Trinder, de la 4-Aminoantipyrine, une protéase, un stabilisateur de protéase, et un ferrocyanure, ce réactif Trinder, au moins, étant inclus dans une composition partielle contenant un réactif Trinder, au moins la 4-Aminoantipyrine étant incluse dans une composition partielle contenant de la 4-Aminoantiyrine, le stabilisant de protéase étant un stabilisant qui augmente le potentiel redox du ferrocyanure à plus de 0,058 V lorsque le ferrocyanure est mélangé avec le stabilisant de protéase, et le potentiel redox étant déterminé dans un système de réaction qui contient le stabilisant de protéase et le ferrocyanure et ne contient pas la protéine glycosylée.
(JA)
少なくともトリンダー試薬、4-アミノアンチピリン、プロテアーゼ、プロテアーゼの安定化剤、及びフェロシアン化物を含む糖化タンパク質測定試薬であって、少なくともトリンダー試薬がトリンダー試薬含有部分組成物に含まれ、少なくとも4-アミノアンチピリンが4-アミノアンチピリン含有部分組成物に含まれ、プロテアーゼの安定化剤が、当該プロテアーゼの安定化剤と混合した場合のフェロシアン化物の酸化還元電位を0.058Vより大きくする安定化剤であり、酸化還元電位が、プロテアーゼの安定化剤及びフェロシアン化物を含み、糖化タンパク質を含まない反応系における酸化還元電位である、糖化タンパク質測定試薬。
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