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1. WO2021001828 - COMPOSITIONS AND METHODS FOR GENERATING INSULIN-PRODUCING BETA CELLS

Publication Number WO/2021/001828
Publication Date 07.01.2021
International Application No. PCT/IL2020/050735
International Filing Date 01.07.2020
IPC
C12N 5/071 2010.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
5Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
07Animal cells or tissues
071Vertebrate cells or tissues, e.g. human cells or tissues
A61L 27/38 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
27Materials for prostheses or for coating prostheses
36containing ingredients of undetermined constitution or reaction products thereof
38Animal cells
A61P 3/10 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
3Drugs for disorders of the metabolism
08for glucose homeostasis
10for hyperglycaemia, e.g. antidiabetics
A61P 5/48 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
5Drugs for disorders of the endocrine system
48of the pancreatic hormones
Applicants
  • BETALIN THERAPEUTICS LTD. [IL]/[IL]
Inventors
  • GOLDMAN, Orit
  • KUNICHER, Nikolai
  • VECSLER, Manuela
  • TREVES, Avi
Agents
  • WEBB, Cynthia
  • ARONIS, Zeev
  • BURSTEIN, Tal
  • FINAROV, Igal
  • GANOR, Sharon
  • HORNIK, Vered
  • NOY, Adi
  • POTASH, Shay
  • RAZ, Sefi
  • SCHICKLER, Hedva
  • SCHVARTZ, Iris
  • TRAVITSKY, Nina
  • WAINSCHTEIN, Silvy
  • WEBB, Yael
  • ZIPOR, Gadi
Priority Data
62/869,03801.07.2019US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) COMPOSITIONS AND METHODS FOR GENERATING INSULIN-PRODUCING BETA CELLS
(FR) COMPOSITIONS ET PROCÉDÉS DE GÉNÉRATION DE CELLULES BÊTA PRODUCTRICES D'INSULINE
Abstract
(EN)
Compositions and methods for generating insulin-producing beta cells from pluripotent stem cells are provided. The compositions and methods of the present invention involve stepwise differentiation while the differentiating cells are cultured on a lung tissue-derived acellular scaffold.
(FR)
L'invention concerne des compositions et des procédés de génération de cellules bêta productrices d'insuline à partir de cellules souches pluripotentes. Les compositions et les procédés de la présente invention impliquent une différenciation progressive tandis que les cellules se différenciant sont cultivées sur un échafaudage acellulaire issu d'un tissu pulmonaire.
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