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1. WO2021001542 - METHOD OF DETERMINING OR INFLUENCING THE CHONDROGENIC POTENTIAL OF MESENCHYMAL STROMAL CELLS

Publication Number WO/2021/001542
Publication Date 07.01.2021
International Application No. PCT/EP2020/068848
International Filing Date 03.07.2020
IPC
C12N 5/0775 2010.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
5Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
07Animal cells or tissues
071Vertebrate cells or tissues, e.g. human cells or tissues
077Mesenchymal cells, e.g. bone cells, cartilage cells, marrow stromal cells, fat cells or muscle cells
0775Mesenchymal stem cells; Adipose-tissue derived stem cells
C12N 5/077 2010.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
5Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
07Animal cells or tissues
071Vertebrate cells or tissues, e.g. human cells or tissues
077Mesenchymal cells, e.g. bone cells, cartilage cells, marrow stromal cells, fat cells or muscle cells
C07K 14/705 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
705Receptors; Cell surface antigens; Cell surface determinants
Applicants
  • AO TECHNOLOGY AG [CH]/[CH]
Inventors
  • STODDART, Martin
  • ALINI, Mauro
Agents
  • SCHMITZ, Joseph
Priority Data
19184241.803.07.2019EP
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) METHOD OF DETERMINING OR INFLUENCING THE CHONDROGENIC POTENTIAL OF MESENCHYMAL STROMAL CELLS
(FR) PROCÉDÉ POUR DÉTERMINER OU INFLUENCER LE POTENTIEL CHONDROGÉNIQUE DE CELLULES STROMALES MÉSENCHYMATEUSES
Abstract
(EN)
A method of increasing the chondrogenic potential mediated by TGFβ of a mesenchymal stromal cell (MSC) or a population of mesenchymal stromal cells (MSCs), comprising the step of increasing the amount of TGFβR1, and/or decreasing the amount of TGFβR2, and/or decreasing the amount of and/or ACVRL1 of the MSC or a population of mesenchymal stromal cells (MSCs).
(FR)
L'invention concerne un procédé d'augmentation du potentiel chondrogénique induit par le TGFβ d'une cellule stromale mésenchymateuse (MSC) ou une population de MSC, comprenant l'étape d'augmentation de la quantité de TGFβR1, et/ou de diminution de la quantité de TGFβR2, et/ou de diminution de la quantité de ACVRL1 de la MSC ou d'une population de MSC.
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