Processing

Please wait...

Settings

Settings

Goto Application

1. WO2021000641 - BIONIC DEGRADABLE ARTIFICIAL NERVE GUIDANCE CONDUIT FOR REGULATING IMMUNE MICROENVIRONMENT AND GUIDING REGENERATION USING TOPOLOGY STRUCTURE, AND PREPARATION METHOD THEREFOR

Publication Number WO/2021/000641
Publication Date 07.01.2021
International Application No. PCT/CN2020/087298
International Filing Date 27.04.2020
IPC
A61L 27/18 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
27Materials for prostheses or for coating prostheses
14Macromolecular materials
18obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
A61L 27/40 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
27Materials for prostheses or for coating prostheses
40Composite materials, i.e. layered or containing one material dispersed in a matrix of the same or different material
A61L 27/50 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
27Materials for prostheses or for coating prostheses
50Materials characterised by their function or physical properties
A61L 27/58 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
27Materials for prostheses or for coating prostheses
50Materials characterised by their function or physical properties
58Materials at least partially resorbable by the body
A61F 2/02 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
2Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
02Prostheses implantable into the body
Applicants
  • 南开大学 NANKAI UNIVERSITY [CN]/[CN]
Inventors
  • 董显豪 DONG, Xianhao
  • 孔德领 KONG, Deling
  • 朱美峰 ZHU, Meifeng
Agents
  • 北京劲创知识产权代理事务所(普通合伙) BEIJING JINCHUANG IP AGENCY FIRM
Priority Data
201910597114.104.07.2019CN
Publication Language Chinese (ZH)
Filing Language Chinese (ZH)
Designated States
Title
(EN) BIONIC DEGRADABLE ARTIFICIAL NERVE GUIDANCE CONDUIT FOR REGULATING IMMUNE MICROENVIRONMENT AND GUIDING REGENERATION USING TOPOLOGY STRUCTURE, AND PREPARATION METHOD THEREFOR
(FR) CONDUIT DE GUIDAGE DE NERF ARTIFICIEL DÉGRADABLE BIONIQUE POUR RÉGULER LE MICROENVIRONNEMENT IMMUNITAIRE ET GUIDER LA RÉGÉNÉRATION À L'AIDE D'UNE STRUCTURE TOPOLOGIQUE, ET SA MÉTHODE DE PRÉPARATION
(ZH) 一种利用拓扑结构调控免疫微环境并引导再生的仿生可降解人工神经导管及其制备方法
Abstract
(EN)
A bionic degradable artificial nerve guidance conduit for regulating the immune microenvironment and guiding regeneration using a topology structure, comprising: a housing (1) and an inner fiber (2). The housing (1) is made of a nanolevel first material of a randomly distributed topology structure, and the degradation time thereof is 12-24 months so as to match the nerve scar formation cycle and effectively prevent the filtration of surrounding tissues. Moreover, the housing (1) has pores so as not to affect the nutrient exchange and the material delivery of a nerve cell during regeneration. The inner fiber (2) is made of a nanolevel second material of a highly oriented topology structure, and the degradation time thereof is 3-10 months so as to match the nerve regeneration rate, which can guide a plurality of nerve cells and other histiocytes to perform oriented adhesion, migration, and proliferation along the guide structure thereof, and regulate macrophages so as to further promote neuroregeneration.
(FR)
L'invention concerne un conduit de guidage de nerf artificiel dégradable bionique pour réguler le microenvironnement immunitaire et guider la régénération à l'aide d'une structure topologique, comprenant : un boîtier (1) et une fibre interne (2). Le boîtier (1) est constitué d'un premier matériau à l'échelle nanométrique d'une structure topologique répartie de manière aléatoire, et son temps de dégradation est de 12 à 24 mois de façon à correspondre au cycle de formation de cicatrice nerveuse et à empêcher efficacement la filtration de tissus environnants. De plus, le boîtier (1) a des pores de façon à ne pas affecter l'échange de nutriments et la distribution de matériau d'une cellule nerveuse pendant la régénération. La fibre interne (2) est constituée d'un second matériau à l'échelle nanométrique d'une structure topologique hautement orientée, et son temps de dégradation est de 3 à 10 mois de façon à correspondre au taux de régénération nerveuse, qui peut guider une pluralité de cellules nerveuses et d'autres histiocytes pour effectuer une adhérence, une migration et une prolifération orientées le long de la structure de guidage associée, et pour réguler les macrophages de façon à favoriser davantage la neurorégénération.
(ZH)
一种利用拓扑结构调控免疫微环境并引导再生的仿生可降解人工神经导管,包括:外壳(1)和内纤维(2)。外壳(1)是具有无规则分布拓扑结构的纳米级第一材料,其降解时间为12-24个月,从而与神经瘢痕形成周期匹配,有效防止周围组织的浸润,且外壳(1)有孔隙,从而不影响再生过程中神经细胞的营养交换与物质传递。内纤维(2)是具有高度取向拓扑结构的微米级第二材料,其降解时间为3-10个月,从而与神经再生速度相匹配,能够引导多种神经细胞以及其它组织细胞沿其引导结构取向黏附、迁移与增殖,调控巨噬细胞从而进一步促进神经再生。
Latest bibliographic data on file with the International Bureau