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1. WO2020257740 - IMMUNOME WIDE ASSOCIATION STUDIES TO IDENTIFY CONDITION-SPECIFIC ANTIGENS

Publication Number WO/2020/257740
Publication Date 24.12.2020
International Application No. PCT/US2020/038856
International Filing Date 20.06.2020
IPC
C12Q 1/68 2018.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
68involving nucleic acids
G01N 33/50 2006.01
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48Biological material, e.g. blood, urine; Haemocytometers
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
G01N 33/574 2006.01
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48Biological material, e.g. blood, urine; Haemocytometers
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53Immunoassay; Biospecific binding assay; Materials therefor
574for cancer
G01N 33/68 2006.01
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48Biological material, e.g. blood, urine; Haemocytometers
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
68involving proteins, peptides or amino acids
CPC
G16B 20/50
GPHYSICS
16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
BBIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
20ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
50Mutagenesis
G16B 35/20
GPHYSICS
16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
BBIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
35ICT specially adapted for in silico combinatorial libraries of nucleic acids, proteins or peptides
20Screening of libraries
G16B 40/00
GPHYSICS
16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
BBIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
40ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding
Applicants
  • SERIMMUNE INC. [US]/[US]
Inventors
  • SHON, John
  • HAYNES, Winston, A.
  • DAUGHERTY, Patrick, Sean
Agents
  • HURT, Nicholas, S.
  • ARGENTIERI, Steven, R.
  • BRODOWSKI, Michael, H.
  • BIEKER, Kristina
  • ASHRAF, Shovon
Priority Data
62/864,90921.06.2019US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) IMMUNOME WIDE ASSOCIATION STUDIES TO IDENTIFY CONDITION-SPECIFIC ANTIGENS
(FR) ÉTUDES D'ASSOCIATIONS LARGES D'IMMUNOMES POUR IDENTIFIER DES ANTIGÈNES SPÉCIFIQUES À UNE AFFECTION
Abstract
(EN)
The present invention provides compositions and methods that can be used to identify an antigen or epitope region of an antigen specific for a disease or other condition. Such methods incorporate k-mer binding statistics to serum antibody from condition and control cohort samples to predict the suitability of antigen sequences identified as relevant to the disease or condition as antigen markers. Also disclosed herein are systems for performing the same.
(FR)
La présente invention concerne des compositions et des méthodes qui peuvent être utilisées pour identifier un antigène ou une région d'épitope d'un antigène spécifique pour une maladie ou une autre affection. De telles méthodes incorporent des statistiques de liaison de k-mères à un anticorps sérique provenant d'échantillons d'une cohorte témoin ou d'une cohorte ayant l'affection en question pour prédire le caractère approprié de séquences antigéniques identifiées comme pertinentes pour la maladie ou l'affection en tant que marqueurs antigéniques. La présente invention concerne en outre des systèmes pour les mettre en œuvre.
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