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1. WO2020256828 - REUSE AND RECYCLING FOR POLYMER SYNTHESIS

Publication Number WO/2020/256828
Publication Date 24.12.2020
International Application No. PCT/US2020/030004
International Filing Date 27.04.2020
IPC
B01J 19/00 2006.01
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
19Chemical, physical or physico-chemical processes in general; Their relevant apparatus
C12P 19/34 2006.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
19Preparation of compounds containing saccharide radicals
26Preparation of nitrogen-containing carbohydrates
28N-glycosides
30Nucleotides
34Polynucleotides, e.g. nucleic acids, oligoribonucleotides
C07H 21/04 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
21Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
04with deoxyribosyl as saccharide radical
CPC
B01J 19/0006
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
19Chemical, physical or physico-chemical processes in general; Their relevant apparatus
0006Controlling or regulating processes
B01J 19/0046
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
19Chemical, physical or physico-chemical processes in general; Their relevant apparatus
0046Sequential or parallel reactions, e.g. for the synthesis of polypeptides or polynucleotides; Apparatus and devices for combinatorial chemistry or for making molecular arrays
B01J 19/06
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
19Chemical, physical or physico-chemical processes in general; Their relevant apparatus
06Solidifying liquids
B01J 19/245
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
19Chemical, physical or physico-chemical processes in general; Their relevant apparatus
24Stationary reactors without moving elements inside
245placed in series
B01J 19/2465
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
19Chemical, physical or physico-chemical processes in general; Their relevant apparatus
24Stationary reactors without moving elements inside
2455provoking a loop type movement of the reactants
2465externally, i.e. the mixture leaving the vessel and subsequently re-entering it
B01J 2219/00186
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
2219Chemical, physical or physico-chemical processes in general; Their relevant apparatus
00049Controlling or regulating processes
00186controlling the composition of the reactive mixture
Applicants
  • MICROSOFT TECHNOLOGY LICENSING, LLC [US]/[US]
Inventors
  • NGUYEN, Bichlien Hoang
  • STRAUSS, Karin
  • KELLEY, Douglas P.
Agents
  • SWAIN, Cassandra T.
  • ADJEMIAN, Monica
  • BARKER, Doug
  • CHATTERJEE, Aaron C.
  • CHEN, Wei-Chen Nicholas
  • CHOI, Daniel
  • CHURNA, Timothy
  • DINH, Phong
  • EVANS, Patrick
  • GABRYJELSKI, Henry
  • GUPTA, Anand
  • HINOJOSA-SMITH, Brianna L.
  • HWANG, William C.
  • JARDINE, John S.
  • LEE, Sunah
  • LEMMON, Marcus
  • MARQUIS, Thomas
  • MEYERS, Jessica
  • ROPER, Brandon
  • SPELLMAN, Steven
  • SULLIVAN, Kevin
  • WALKER, Matt
  • WIGHT, Stephen A.
  • WISDOM, Gregg
  • WONG, Ellen
  • WONG, Thomas S.
  • ZHANG, Hannah
  • TRAN, Kimberly
Priority Data
16/443,63717.06.2019US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) REUSE AND RECYCLING FOR POLYMER SYNTHESIS
(FR) RÉUTILISATION ET RECYCLAGE POUR SYNTHÈSE DE POLYMÈRES
Abstract
(EN)
Reagents and solvents used for polymer synthesis are reused or recycled rather than discarded. The outflow from each step of polymer synthesis may be collected separately in one of multiple dedicated containers. Reuse returns the outflow from a step of polymer synthesis back to an input of a polymer synthesizer for subsequent use in that same step. Recycling processes the outflow from one or more steps of polymer synthesis to restore original concentrations or purity levels for use in a later synthesis run. Quality control analysis may determine if outflow collected from a polymer synthesizer is reused or recycled. These techniques reduce reagent cost and waste quantity. These techniques may be used with phosphoramidite or enzyme-based synthesis of deoxyribonucleic acid (DNA).
(FR)
Selon l'invention, les réactifs et les solvants utilisés pour la synthèse de polymères sont réutilisés ou recyclés plutôt que jetés. Le flux sortant de chaque étape de synthèse de polymère peut être collecté séparément dans l'un de multiples récipients dédiés. La réutilisation renvoie le flux sortant d'une étape de synthèse de polymère vers une entrée d'un synthétiseur de polymère pour une utilisation ultérieure dans cette même étape. Le recyclage traite le flux sortant d'une ou plusieurs étapes de synthèse de polymère pour restaurer les concentrations ou les niveaux de pureté d'origine pour une réutilisation dans un cycle de synthèse ultérieur. Une analyse de contrôle de qualité peut déterminer si un flux sortant collecté à partir d'un synthétiseur de polymère est réutilisé ou recyclé. Ces techniques réduisent le coût des réactifs et la quantité de déchets. Ces techniques peuvent être utilisées avec la synthèse à base de phosphoramidite ou d'enzyme d'acide désoxyribonucléique (ADN).
Also published as
Latest bibliographic data on file with the International Bureau