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1. WO2020250207 - SMALL CATIONIC ORTHO-5,15-DI-HETEROARYL-PORPHYRINS DERIVATIVES AND THEIR APPLICATIONS IN PHOTOINACTIVATION OF MICROORGANISMS

Publication Number WO/2020/250207
Publication Date 17.12.2020
International Application No. PCT/IB2020/055584
International Filing Date 15.06.2020
IPC
C09B 47/00 2006.01
CCHEMISTRY; METALLURGY
09DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
BORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES; MORDANTS; LAKES
47Porphines; Azaporphines
CPC
C09B 47/00
CCHEMISTRY; METALLURGY
09DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
BORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES ; , e.g. PIGMENTS; MORDANTS; LAKES
47Porphines; Azaporphines
Applicants
  • UNIVERSIDADE DE COIMBRA [PT]/[PT]
Inventors
  • MIGUÉNS PEREIRA, Maria
  • DUARTE JORGE DA SILVA, Gabriela Conceição
  • DA SILVA ARNAUT MOREIRA, Luís Guilerme
  • DOS SANTOS VINAGREIRO, Carolina
  • BLANCO, Kate Cristina
  • SALVADOR BAGNATO, Vanderlei
  • MAYUMI INADA, Natalia
Agents
  • VIEIRA PEREIRA FERREIRA, Maria Silvina
Priority Data
11558114.06.2019PT
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) SMALL CATIONIC ORTHO-5,15-DI-HETEROARYL-PORPHYRINS DERIVATIVES AND THEIR APPLICATIONS IN PHOTOINACTIVATION OF MICROORGANISMS
(FR) PETITS DÉRIVÉS CATIONIQUES D'ORTHO-5,15-DI-HÉTÉROARYL-PORPHYRINES ET LEURS APPLICATIONS DANS LA PHOTOINACTIVATION DE MICRO-ORGANISMES
Abstract
(EN)
The present invention relates to small cationic ortho-5,15-di-heteroaryl porphyrin derivatives, in particular porphyrins, chlorins or bacteriochlorin of formula (I).or pharmaceutically acceptable salts thereof. This invention also relates to the use of the above-mentioned cationic ortho-5,10-di-heteroaryl porphyrin derivatives of Formula (I) or a pharmaceutically acceptable salts thereof, in photodynamic inactivation of microorganisms, where the referred derivatives are able to treat the same in the presence of an adequate light. The present invention also describes pharmaceutical compositions comprising one or more of the cationic ortho-5,10-di-heteroaryl porphyrin derivatives, in particular prophyrins, chlorins or bacteriochlorins of Formula (I), or pharmaceutically acceptable salts thereof, for the treatment of bacterial and/or fungi and/or yeasts and/or viral infections, in humans or animals.
(FR)
La présente invention concerne de petits dérivés de porphyrines ortho-5,15-di-hétéroaryl cationiques, en particulier des porphyrines, des chlorines ou une bactériochlorine de formule (I), ou des sels pharmaceutiquement acceptables associés. L'invention concerne également l'utilisation des dérivés de porphyrines ortho-5,15-di-hétéroaryl cationiques susmentionnés de formule (I) ou des sels pharmaceutiquement acceptables associés, dans l'inactivation photodynamique de microorganismes, les dérivés mentionnés pouvant traiter ceux-ci en présence d'une lumière adéquate. La présente invention concerne également des compositions pharmaceutiques comprenant un ou plusieurs des dérivés de porphyrine ortho-5,10-di-hétéroaryl cationiques, en particulier des porphyrines, des chlorines ou des bactériochlorines de formule (I), ou des sels pharmaceutiquement acceptables associés, pour le traitement de bactéries et/ou de champignons et/ou de levures et/ou d'infections virales, chez l'homme ou l'animal.
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