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1. WO2020247633 - THIARABINE- AND THIARABINE PRODRUG-BASED TREATMENTS

Publication Number WO/2020/247633
Publication Date 10.12.2020
International Application No. PCT/US2020/036125
International Filing Date 04.06.2020
IPC
A61K 31/5415 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
54having six-membered rings with at least one nitrogen and at least one sulfur as the ring hetero atoms, e.g. sulthiame
5415ortho- or peri-condensed with carbocyclic ring systems, e.g. phenothiazine, chlorpromazine, piroxicam
A61K 31/7068 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
70Carbohydrates; Sugars; Derivatives thereof
7042Compounds having saccharide radicals and heterocyclic rings
7052having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
706containing six-membered rings with nitrogen as a ring hetero atom
7064containing condensed or non-condensed pyrimidines
7068having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
Applicants
  • SOUTHERN RESEARCH INSTITUTE [US]/[US]
Inventors
  • MOUKHA-CHAFIQ, Omar
  • SUTO, Mark J.
  • LIU, Jie
  • BOOHAKER, Rebecca
Agents
  • SHORTELL, D. Brian
  • KATZ, Mitchell, A.
  • BROWN, Charley, F.
  • MEADOWNS, Brian, C.
  • MARTY, Scott, D.
Priority Data
62/857,68605.06.2019US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) THIARABINE- AND THIARABINE PRODRUG-BASED TREATMENTS
(FR) TRAITEMENTS À BASE DE PROMÉDICAMENT DE THIARABINE ET DE THIARABINE
Abstract
(EN)
The present disclosure is concerned with combination therapies that include sulfur- based nucleotide and nucleoside compounds for the treatment of various cancers such as, for example, sarcomas, carcinomas, hematological cancers, solid tumors, breast cancer, cervical cancer, gastrointestinal cancer, colorectal cancer, brain cancer, skin cancer, prostate cancer, ovarian cancer, bladder cancer, thyroid cancer, testicular cancer, pancreatic cancer, endometrial cancer, melanomas, gliomas, leukemias, lymphomas, chronic myeloproliferative disorders, myelodysplastic syndromes, myeloproliferative neoplasms, and plasma cell neoplasms (myelomas). This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
(FR)
La présente invention concerne des polythérapies qui comprennent des composés de nucléotide et de nucléoside à base de soufre pour le traitement de divers cancers tels que, par exemple les sarcomes, les carcinomes, les cancers hématologiques, les tumeurs solides, le cancer du sein, le cancer du col de l'utérus, le cancer gastro-intestinal, le cancer colorectal, le cancer du cerveau, le cancer de la peau, le cancer de la prostate, le cancer de l'ovaire, le cancer de la vessie, le cancer de la thyroïde, le cancer du testicule, le cancer du pancréas, le cancer de l'endomètre, les mélanomes, les gliomes, les leucémies, les lymphomes, les syndromes myéloprolifératifs chroniques, les syndromes myélodysplasiques, les néoplasmes myéloprolifératifs et les néoplasmes de cellules plasmatiques (myélomes). Cet abrégé est destiné à être utilisé comme outil de balayage à des fins de recherche dans l'art particulier et n'est pas destiné à limiter la présente invention.
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