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1. WO2020238148 - ETHANOL FOAM HARDENER APPLIED TO TREATMENT OF VASCULAR ANOMALIES AND PREPARATION METHOD

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Publication Number WO/2020/238148
Publication Date 03.12.2020
International Application No. PCT/CN2019/124643
International Filing Date 11.12.2019
IPC
A61K 47/34 2017.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
34Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
A61K 9/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
A61P 9/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
9Drugs for disorders of the cardiovascular system
CPC
A61K 31/045
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
045Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
A61K 47/24
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
24containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
A61K 47/26
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
26Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
A61K 47/36
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
36Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
A61K 9/122
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
10Dispersions; Emulsions
12Aerosols; Foams
122Foams; Dry foams
A61P 35/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
Applicants
  • 山东大学齐鲁医院 QILU HOSPITAL OF SHANDONG UNIVERSITY [CN]/[CN]
Inventors
  • 刘少华 LIU, Shaohua
  • 张涵恕 ZHANG, Hanshu
  • 杨爱军 YANG, Aijun
  • 刘怡然 LIU, Yiran
Agents
  • 济南圣达知识产权代理有限公司 JINAN SHENGDA INTELLECTUAL PROPERTY AGENCY CO., LTD.
Priority Data
201910450705.628.05.2019CN
Publication Language Chinese (ZH)
Filing Language Chinese (ZH)
Designated States
Title
(EN) ETHANOL FOAM HARDENER APPLIED TO TREATMENT OF VASCULAR ANOMALIES AND PREPARATION METHOD
(FR) DURCISSEUR DE MOUSSE D'ÉTHANOL APPLIQUÉ AU TRAITEMENT D'ANOMALIES VASCULAIRES ET PROCÉDÉ DE PRÉPARATION
(ZH) 一种应用于治疗脉管异常的乙醇泡沫硬化剂及制备方法
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Abstract
(EN)
An ethanol foam hardener applied to the treatment of vascular anomalies and a preparation method, comprising absolute ethanol, water, Tween 80, and a stabilizer. Further comprised is hyaluronic acid. The ethanol foam hardener comprises 32-42% absolute ethanol, 0.5-2% Tween 80, 0-25 (not comprising 0) egg yolk lecithin, 0-2% (not comprising 0) hyaluronic acid, and the remainder is water. The stabilizer is hyaluronic acid or glycerin. A Tessari method is used to prepare foam, which may significantly reduce the side effects of ethanol while not changing the original therapeutic effects of the ethanol.
(FR)
L'invention concerne un durcisseur de mousse d'éthanol appliqué au traitement d'anomalies vasculaires et un procédé de préparation, comprenant de l'éthanol absolu, de l'eau, du Tween 80 et un stabilisant. L'invention concerne en outre de l'acide hyaluronique. Le durcisseur de mousse d'éthanol comprend de 32 à 42 % d'éthanol absolu, des 0,5 à 2 % de Tween 80, des 1 à 25 lécithines de jaune d'œuf, de 1 à 2 % d'acide hyaluronique, et le reste étant de l'eau. Le stabilisant est l'acide hyaluronique ou la glycérine. Une méthode de Tessari est utilisée pour préparer la mousse, ce qui peut réduire de manière significative les effets secondaires de l'éthanol tout en ne modifiant pas ses effets thérapeutiques originaux.
(ZH)
一种应用于脉管异常的乙醇泡沫硬化剂及制备方法，包括无水乙醇、水、吐温80、稳定剂。还包括透明质酸，无水乙醇32-42％、吐温80 0.5-2％、蛋黄卵磷脂0-25（不包括0）、透明质酸0-2％（不包括0），剩余为水。稳定剂为透明质酸或甘油，利用Tessari法制备泡沫，在不改变乙醇原有治疗效果的同时，显著降低其副作用。
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