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1. WO2020232526 - METHOD FOR ACETYLATION OF CANNABINOIDS

Publication Number WO/2020/232526
Publication Date 26.11.2020
International Application No. PCT/CA2019/051350
International Filing Date 20.09.2019
IPC
C07D 311/80 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
311Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
02ortho- or peri-condensed with carbocyclic rings or ring systems
78Ring systems having three or more relevant rings
80Dibenzopyrans; Hydrogenated dibenzopyrans
A61K 31/352 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
335having oxygen as the only ring hetero atom, e.g. fungichromin
35having six-membered rings with one oxygen as the only ring hetero atom
352condensed with carbocyclic rings, e.g. cannabinols, methantheline
CPC
A61K 31/352
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
335having oxygen as the only ring hetero atom, e.g. fungichromin
35having six-membered rings with one oxygen as the only ring hetero atom
352condensed with carbocyclic rings, e.g. cannabinols, methantheline
A61P 25/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
B01D 1/222
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
DSEPARATION
1Evaporating
22by bringing a thin layer of the liquid into contact with a heated surface
222In rotating vessels; vessels with movable parts
B01D 11/0492
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
DSEPARATION
11Solvent extraction
04of solutions which are liquid
0492Applications, solvents used
B01D 3/10
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
DSEPARATION
3Distillation or related exchange processes in which liquids are contacted with gaseous media, e.g. stripping
10Vacuum distillation
B01D 3/143
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
DSEPARATION
3Distillation or related exchange processes in which liquids are contacted with gaseous media, e.g. stripping
14Fractional distillation ; or use of a fractionation or rectification column
143by two or more of a fractionation, separation or rectification step
Applicants
  • NEXTLEAF SOLUTIONS LTD [CA]/[CA]
Inventors
  • PAL, Krupal Devendra
  • KO, Ryan Delmoral
  • HUGHES, Brock Aston
  • CASSELMAN, Ivan Jason
Agents
  • LOVELAND, Damien Gerard
Priority Data
16/415,78217.05.2019US
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) METHOD FOR ACETYLATION OF CANNABINOIDS
(FR) PROCÉDÉ POUR L'ACÉTYLATION DE CANNABINOÏDES
Abstract
(EN) A process for producing THC-O-acetate using a succession of distillation, salting-out assisted liquid-liquid extractions (SALLEs), and solvent recovery techniques. Tetrahydrocannabinol (THC) in cannabis oil reacts with acetic anhydride under reflux to produce THC-O-acetate and acetic acid. The resulting crude product is distilled and subjected to a SALLE with hexane followed by a SALLE with petroleum ether, before being distilled again in order to obtain a refined, THC-O-acetate product.
(FR) L'invention concerne un procédé de production de THC-O-acétate, utilisant une succession de techniques de distillation, d'extraction liquide-liquide assistée par relargage (SALLE) et de récupération de solvants. Le tétrahydrocannabinol (THC, dans l'huile de cannabis réagit avec l'anhydride acétique au reflux pour produire le THC-O-acétate et de l'acide acétique. Le produit brut obtenu est distillé et soumis à une extraction SALLE avec de l'hexane, puis à une extraction SALLE avec de l'éther de pétrole, avant nouvelle distillation dans le but d'obtenir un produit THC-O-acétate raffiné.
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