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1. WO2020231670 - TRIAMCINOLONE ACETONIDE-LOADED LIPOSOMES TOPICAL OPHTHALMIC FORMULATIONS FOR PREVENTION OF MACULAR THICKENING AND ITS ASSOCIATED VISUAL OUTCOMES AFTER LENS SURGERY

Publication Number WO/2020/231670
Publication Date 19.11.2020
International Application No. PCT/US2020/031417
International Filing Date 05.05.2020
IPC
A61K 9/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
A61K 9/127 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
10Dispersions; Emulsions
127Liposomes
A61K 31/58 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
56Compounds containing cyclopentahydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
58containing heterocyclic rings, e.g. aldosterone, danazol, stanozolol, pancuronium, digitogenin
A61P 27/02 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
27Drugs for disorders of the senses
02Ophthalmic agents
CPC
A61K 31/58
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
56Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives, e.g. steroids
58containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
A61K 9/0048
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
0012Galenical forms characterised by the site of application
0048Eye, e.g. artificial tears
A61K 9/1271
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
10Dispersions; Emulsions
127Liposomes
1271Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers
A61P 27/02
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
27Drugs for disorders of the senses
02Ophthalmic agents
Applicants
  • OPKO PHARMACEUTICALS, LLC [US]/[US]
Inventors
  • SANTOS, Arturo
  • HSIAO, Jane H.
  • NAVARRO, Jose
  • ALTAMIRANO, Juan C.
  • GONZALEZ, Alejandro
Agents
  • BROWDER, Monte R.
Priority Data
16/426,71230.05.2019US
62/848,90716.05.2019US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) TRIAMCINOLONE ACETONIDE-LOADED LIPOSOMES TOPICAL OPHTHALMIC FORMULATIONS FOR PREVENTION OF MACULAR THICKENING AND ITS ASSOCIATED VISUAL OUTCOMES AFTER LENS SURGERY
(FR) FORMULATIONS OPHTALMIQUES TOPIQUES CONTENANT DES LIPOSOMES CHARGÉS D'ACÉTONIDE DE TRIAMCINOLONE POUR LA PRÉVENTION DE L'ÉPAISSISSEMENT MACULAIRE ET DE SES RÉSULTATS VISUELS ASSOCIÉS APRÈS UNE CHIRURGIE DU CRISTALLIN
Abstract
(EN)
The invention relates to triamcinolone acetonide-loaded liposomes topical ophthalmic formulations for prevention of macular thickening and its associated visual outcomes after lens surgery. The liposomal formulation comprises thermodynamically self-forming liposomes which are useful in topical form to treat posterior segment diseases of the eye.
(FR)
L'invention concerne des formulations ophtalmiques topiques contenant des liposomes chargés d'acétonide de triamcinolone pour la prévention de l'épaississement maculaire et de ses résultats visuels associés après une chirurgie du cristallin. La formulation liposomale comprend des liposomes à formation autonome par voie thermodynamique qui sont utiles sous forme topique pour traiter des maladies du segment postérieur de l'oeil.
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