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1. WO2020230108 - TREATMENT OF ISCHEMIC STROKE WITH APTAMERS TARGETING TLR-4

Publication Number WO/2020/230108
Publication Date 19.11.2020
International Application No. PCT/IB2020/054654
International Filing Date 16.05.2020
IPC
A61K 31/711 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
70Carbohydrates; Sugars; Derivatives thereof
7088Compounds having three or more nucleosides or nucleotides
711Natural deoxyribonucleic acids, i.e. containing only 2'-deoxyriboses attached to adenine, guanine, cytosine or thymine and having 3'-5' phosphodiester links
A61P 21/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
21Drugs for disorders of the muscular or neuromuscular system
A61P 25/28 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
28for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
A61P 9/10 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
9Drugs for disorders of the cardiovascular system
10for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
CPC
A61K 31/711
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
70Carbohydrates; Sugars; Derivatives thereof
7088Compounds having three or more nucleosides or nucleotides
711Natural deoxyribonucleic acids, i.e. containing only 2'-deoxyriboses attached to adenine, guanine, cytosine or thymine and having 3'-5' phosphodiester links
A61P 21/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
21Drugs for disorders of the muscular or neuromuscular system
A61P 25/28
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
28for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
A61P 9/10
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
9Drugs for disorders of the cardiovascular system
10for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Applicants
  • APTATARGETS, S.L. [ES]/[ES]
Inventors
  • SEGARRA DE LA PEÑA, David
  • BOSCÁ GOMAR, Lisardo
  • LIZASOAIN HERNÁNDEZ, Ignacio
  • HERNÁNDEZ JIMÉNEZ, Macarena
  • MORO SÁNCHEZ, María Ángeles
  • PÉREZ RODRÍGUEZ, Diego
  • ZARABOZO LEAL, María Eugenia
Priority Data
19382424.027.05.2019EP
19382425.727.05.2019EP
62/849,06816.05.2019US
62/849,07216.05.2019US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) TREATMENT OF ISCHEMIC STROKE WITH APTAMERS TARGETING TLR-4
(FR) TRAITEMENT D'UN ACCIDENT ISCHÉMIQUE CÉRÉBRAL AVEC DES APTAMÈRES CIBLANT TLR -4
Abstract
(EN)
The present disclosure related to methods to treat, prevent (e.g., suppress, inhibit or delay), or ameliorate the symptoms of ischemic stroke comprising administering an aptamer of the present disclosure to a subject in need thereof, alone or combination with other pharmacological and/or surgical interventions. In a particular aspect, the aptamers of the present disclosure are administered before, during, of after thrombolysis (e.g., thrombectomy) or any combination thereof. The disclosure also provides specific doses and dosage regimes.
(FR)
La présente invention concerne des procédés pour traiter, prévenir (par exemple supprimer, inhiber ou retarder), ou soulager les symptômes d'un accident vasculaire cérébral ischémique, comprenant l'administration d'un aptamère de la présente invention à un sujet qui en a besoin, seul ou en combinaison avec d'autres interventions pharmacologiques et/ou chirurgicales. Dans un aspect particulier, les aptamères de la présente invention sont administrés avant, pendant et/ou après une thrombolyse (par exemple, une thrombectomie). L'invention concerne également des doses et régimes posologiques spécifiques.
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