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1. WO2020229502 - USE OF CO-CRYSTALS OF TRAMADOL AND CELECOXIB FOR TREATING PAIN WHILE REDUCING THE ABUSE LIABILITY OF TRAMADOL


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INTERNATIONAL SEARCH REPORT (ISR)
Part 1:  1  2  3  4  5  6          Part 2:  A  B  C  D  E 
International application No. Applicant's or agent's file reference
PCT/EP2020/063250 P2109PC00
International filing date (day/month/year) (Earliest) Priority Date (day/month/year)
13 May 2020 14 May 2019
Applicant
ESTEVE PHARMACEUTICALS, S.A.
FOR FURTHER ACTION: See Form PCT/ISA/220 as well as, where applicable, item 5 below.
This international search report has been prepared by this International Searching Authority and is transmitted to the applicant according to Article 18. A copy is being transmitted to the International Bureau.
It is also accompanied by a copy of each prior art document cited in this report.
1. Basis of the report
a. With regard to the language, the international search was carried out on the basis of:
the international application in the language in which it was filed.
a translation of the international application into                                          which is the language of a translation furnished for the purposes of international search (Rules 12.3(a) and 23.1(b)).
b.
This international search report has been established taking into account the rectification of an obvious mistake authorized by or notified to this Authority under Rule 91 (Rule 43.6bis(a)).
c.
With regard to any nucleotide and/or amino acid sequence disclosed in the international application, the international search was carried out on the basis of a sequence listing:
2. Certain claims were found unsearchable
3. Unity of invention is lacking
4. Title of the invention
The text is approved as submitted by the applicant.
The text has been established by this Authority to read as follows:
5. Abstract
The text is approved as submitted by the applicant.
The text has been established, according to Rule 38.2, by this Authority as it appears in Box No. IV. The applicant may, within one month from the date of mailing of this international search report, submit comments to this Authority.
6. Drawings
a.
The figure of the drawings to be published with the abstract is Figure No. ____________
as suggested by the applicant.
as selected by this Authority, because the applicant failed to suggest a figure.
as selected by this Authority, because this figure better characterizes the invention.
b.
none of the figures is to be published with the abstract.

A. CLASSIFICATION OF SUBJECT MATTER

     A61K 31/135 (2006.01)i; A61K 31/415 (2006.01)i; A61P 29/00 (2006.01)i
According to International Patent Classification (IPC) or to both national classification and IPC

B. FIELDS SEARCHED

Minimum documentation searched (classification system followed by classification symbols):
     A61K; A61P
Documentation searched other than minimum documentation to the extent that such documents are included in the fields searched:
Electronic data base consulted during the international search (name of data base and, where practicable, search terms used):
EPO-Internal, BIOSIS, CHEM ABS Data, EMBASE, WPI Data

C. DOCUMENTS CONSIDERED TO BE RELEVANT

Category* Citation of document, with indication, where appropriate, of the relevant passages Relevant to claim No.
(1)
A
WO 2011151080 A1 (ESTEVE LABOR DR [ES]; SOLER RANZANI LUIS [ES] ET AL.) 08 December 2011 (2011-12-08)
1-13
cited in the application
claims 1-5
(2)
A
EP 2586432 A2 (ESTEVE LABOR DR [ES]) 01 May 2013 (2013-05-01)
1-13
claims 6-8,14,15
(3)
A
SEBASTIÁN VIDELA ET AL, "Single-dose pharmacokinetics of co-crystal of tramadol-celecoxib: Results of a four-way randomized open-label phase I clinical trial in healthy subjects", BRITISH JOURNAL OF CLINICAL PHARMACOLOGY.,Vol. 83, No. 12, 20 September 2017 (2017-09-20), page 2718-2728,
XP055636240
1-13
abstract
page 2722; table 2
page 2723; figures 3,4
(4)
A
Helendooner ET AL, "Pharmacokinetics ofTramadol andCelecoxib inJapanese andCaucasian Subjects Following Administration ofCo-Crystal ofTramadol-Celecoxib (CTC): ARandomised, Open-Label Study", 28 June 2018 (2018-06-28), page 63-75,
Retrieved from the Internet:
URL:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6394644/pdf/13318_2018_Article_491.pdf
XP055636279
[retrieved on  2019-10-28]
1-13
abstract
(5)
A
EP 2349238 A1 (ESTEVE LABOR DR [ES]) 03 August 2011 (2011-08-03)
1-13
claims 1,10
(6)
A
CARMEN ALMANSA ET AL, "): A Novel API-API Co-crystal for the Treatment of Pain", CRYSTAL GROWTH & DESIGN.,Vol. 17, No. 4, 20 March 2017 (2017-03-20), page 1884-1892,
XP055636403
1-10
abstract
page 1890 - page 1891
(7)
A
JP 2017190328 A (SHIONOGI & CO) 19 October 2017 (2017-10-19)
1-13
claims
(8)
A
JOSÉ LÓPEZ-CEDRÚN ET AL, "Co-crystal of Tramadol-Celecoxib in Patients with Moderate to Severe Acute Post-surgical Oral Pain: A Dose-Finding, Randomised, Double-Blind, Placebo- and Active-Controlled, Multicentre, Phase II Trial", DRUGS IN R AND D,Vol. 18, No. 2, 25 May 2018 (2018-05-25), page 137-148,
XP055636679
1-13
abstract
*
Special categories of cited documents:
"A"
document defining the general state of the art which is not considered to be of particular relevance
"D"
document cited by the applicant in the international application
"E"
earlier application or patent but published on or after the international filing date
"L"
document which may throw doubts on priority claim(s) or which is cited to establish the publication date of another citation or other special reason (as specified)
"O"
document referring to an oral disclosure, use, exhibition or other means
"P"
document published prior to the international filing date but later than the priority date claimed
"T"
later document published after the international filing date or priority date and not in conflict with the application but cited to understand the principle or theory underlying the invention
"X"
document of particular relevance; the claimed invention cannot be considered novel or cannot be considered to involve an inventive step when the document is taken alone
"Y"
document of particular relevance; the claimed invention cannot be considered to involve an inventive step when the document is combined with one or more other such documents, such combination being obvious to a person skilled in the art
"&"
document member of the same patent family

D. INFORMATION ON PATENT FAMILY MEMBERS

Patent document cited in search report Publication date
(day/month/year)
Patent family member(s) Publication date
(day/month/year)
WO 2011151080 A1
08 December 2011
AR 081774 A1
AU 2011260608 A1
BR 112012030704 A2
CA 2798090 A1
CN 102946871 A
CO 6660469 A2
CY 1118813 T1
DK 2575778 T3
EC SP13012368 A
EP 2392319 A1
EP 2575778 A1
EP 3158994 A1
ES 2622192 T3
HR P20170594 T1
HU E033999 T2
IL 222731 A
JP 5800016 B2
JP 2013530952 A
KR 20130093015 A
LT 2575778 T
MX 351507 B
MY 156859 A
NZ 603457 A
PL 2575778 T3
PT 2575778 T
RU 2012157256 A
SG 185385 A1
TN 2012000515 A1
TW 201143760 A
UA 109661 C2
US 2013109659 A1
WO 2011151080 A1
ZA 201208767 B
17 October 2012
22 November 2012
13 September 2016
08 December 2011
27 February 2013
30 April 2013
07 March 2018
18 April 2017
31 January 2013
07 December 2011
10 April 2013
26 April 2017
05 July 2017
16 June 2017
29 January 2018
31 May 2016
28 October 2015
01 August 2013
21 August 2013
10 April 2017
18 October 2017
15 April 2016
31 October 2014
29 September 2017
21 April 2017
20 July 2014
28 December 2012
01 April 2014
16 December 2011
25 September 2015
02 May 2013
08 December 2011
31 July 2013
EP 2586432 A2
01 May 2013
DK 2488169 T3
EC SP12011734 A
EP 2488169 A1
EP 2586432 A2
ES 2402112 T3
PL 2488169 T3
RU 2012120088 A
SI 2488169 T1
SM T201300048 B
TN 2012000075 A1
08 April 2013
30 May 2012
22 August 2012
01 May 2013
29 April 2013
28 June 2013
27 November 2013
31 May 2013
09 July 2013
19 September 2013
EP 2349238 A1
03 August 2011
AU 2009304235 A1
CA 2737754 A1
CN 102186465 A
CY 1118374 T1
DK 2349238 T3
EP 2177215 A1
EP 2349238 A1
ES 2603962 T3
HR P20161526 T1
HU E030976 T2
IL 211785 A
JP 5645830 B2
JP 2012505847 A
KR 20110069860 A
LT 2349238 T
MX 336318 B
MY 156285 A
NZ 591873 A
PL 2349238 T3
PT 2349238 T
RU 2011119608 A
SM T201600439 B
UA 109534 C2
US 2011257134 A1
US 2012172398 A1
US 2014057879 A1
US 2014350110 A1
US 2015196503 A1
US 2015196504 A1
US 2017000806 A1
US 2017027965 A1
US 2019231800 A1
US 2020171055 A1
WO 2010043412 A1
ZA 201102762 B
22 April 2010
22 April 2010
14 September 2011
28 June 2017
12 December 2016
21 April 2010
03 August 2011
02 March 2017
16 December 2016
28 June 2017
31 July 2016
24 December 2014
08 March 2012
23 June 2011
27 December 2016
14 January 2016
29 January 2016
21 December 2012
30 June 2017
24 November 2016
27 November 2012
10 January 2017
10 September 2015
20 October 2011
05 July 2012
27 February 2014
27 November 2014
16 July 2015
16 July 2015
05 January 2017
02 February 2017
01 August 2019
04 June 2020
22 April 2010
28 December 2011
JP 2017190328 A
19 October 2017
JP 6323846 B2
JP 2017190328 A
16 May 2018
19 October 2017
Name and mailing address of the ISA/:
European Patent Office
P.B. 5818, Patentlaan 2, 2280 HV Rijswijk,
Netherlands
Telephone No. (+31-70)340-2040
Facsimile No. (+31-70)340-3016
Date of the actual completion of the international search:
15 July 2020
Date of mailing of the international search report:
23 July 2020
Authorized officer:
Werner, Doris
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