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1. WO2020228705 - PHARMACEUTICAL COMPOSITION FOR HEART TREATMENT AND PROTECTION

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Publication Number WO/2020/228705
Publication Date 19.11.2020
International Application No. PCT/CN2020/089859
International Filing Date 12.05.2020
IPC
A61K 38/16 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
A61K 38/18 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
17from animals; from humans
18Growth factors; Growth regulators
A61P 9/04 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
9Drugs for disorders of the cardiovascular system
04Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
A61P 9/00 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
9Drugs for disorders of the cardiovascular system
CPC
A61K 38/16
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
A61K 38/18
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
17from animals; from humans
18Growth factors; Growth regulators
A61K 38/1875
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
17from animals; from humans
18Growth factors; Growth regulators
1875Bone morphogenic factor; Osteogenins; Osteogenic factor; Bone-inducing factor
A61K 47/42
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
42Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
A61K 47/64
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
50the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
51the non-active ingredient being a modifying agent
62the modifying agent being a protein, peptide or polyamino acid
64Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
A61P 9/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
9Drugs for disorders of the cardiovascular system
Applicants
  • 龚笑海 GONG, Xiaohai [US]/[CN]
Inventors
  • 龚笑海 GONG, Xiaohai
  • 王若璋 WANG, Ruozhang
  • 金坚 JIN, Jian
  • 曲秀霞 QU, Xiuxia
Agents
  • 上海一平知识产权代理有限公司 XU & PARTNERS, LLC.
Priority Data
201910411120.316.05.2019CN
Publication Language Chinese (zh)
Filing Language Chinese (ZH)
Designated States
Title
(EN) PHARMACEUTICAL COMPOSITION FOR HEART TREATMENT AND PROTECTION
(FR) COMPOSITION PHARMACEUTIQUE POUR LE TRAITEMENT ET LA PROTECTION CARDIAQUE
(ZH) 一种心脏治疗和保护的药物组合物
Abstract
(EN) Provided is a composition for heart protection and heart damage treatment. Specifically, provided is a proBMP10-derived BMP10 complex, and a composition including the BMP10 complex, a medicine kit and an application. The BMP10 complex comprises a first complex, a second complex and a third complex, the three complexes being composed of one BMP10 dimer and two BMP10 leader peptides which are covalently or non-covalently linked. The composition may reduce functional and organic damage to the heart caused by anti-tumour drugs.
(FR) L'invention concerne une composition pour la protection cardiaque et le traitement des lésions cardiaques. De façon spécifique, l'invention concerne un complexe BMP10 dérivé de proBMP10, et une composition comprenant le complexe BMP10, un kit de médicaments et une application. Le complexe BMP10 comprend un premier complexe, un deuxième complexe et un troisième complexe, les trois complexes étant constitués d'un dimère BMP10 et de deux peptides de tête BMP10 qui sont liés de manière covalente ou non covalente. La composition peut réduire les dommages fonctionnels et organiques au coeur provoqués par des médicaments anti-tumoraux.
(ZH) 本发明提供了一种保护心脏和治疗心脏损伤的组合物。具体地，本发明提供了衍生自proBMP10的BMP10复合物，以及包含BMP10复合物的组合物、药盒、及其应用。其中，本发明的BMP10复合物包括第一复合物、第二复合物和第三复合物，上述三种复合物由共价或非共价连接的一个BMP10二聚体与两个BMP10前导肽构成。本发明的组合物可以减轻抗肿瘤药物所致心脏功能性和器质性损伤。
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