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1. WO2020227554 - METHODS OF MAKING ANTIBODIES

Publication Number WO/2020/227554
Publication Date 12.11.2020
International Application No. PCT/US2020/031914
International Filing Date 07.05.2020
IPC
C07K 16/28 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18against material from animals or humans
28against receptors, cell surface antigens or cell surface determinants
C12N 5/10 2006.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
5Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
10Cells modified by introduction of foreign genetic material, e.g. virus-transformed cells
CPC
C07K 16/2809
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
18against material from animals or humans
28against receptors, cell surface antigens or cell surface determinants
2803against the immunoglobulin superfamily
2809against the T-cell receptor (TcR)-CD3 complex
C07K 16/2833
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
18against material from animals or humans
28against receptors, cell surface antigens or cell surface determinants
2803against the immunoglobulin superfamily
2833against MHC-molecules, e.g. HLA-molecules
C07K 2317/31
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
2317Immunoglobulins specific features
30characterized by aspects of specificity or valency
31multispecific
Applicants
  • GENENTECH, INC. [US]/[US] (AE, AG, AM, AO, AU, AZ, BA, BB, BF, BH, BJ, BN, BR, BW, BY, BZ, CA, CF, CG, CI, CL, CM, CO, CR, CU, DJ, DM, DO, DZ, EC, EG, GA, GD, GE, GH, GM, GN, GQ, GT, GW, HN, ID, IL, IR, JO, JP, KE, KG, KH, KM, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LY, MA, MD, ME, MG, ML, MN, MR, MW, MX, MY, MZ, NA, NE, NG, NI, NZ, OM, PA, PE, PG, PH, QA, RU, RW, SA, SC, SD, SG, SL, SN, ST, SV, SY, SZ, TD, TG, TH, TJ, TM, TN, TT, TZ, UA, UG, US, UZ, VC, VN, WS, ZA, ZM, ZW)
  • F. HOFFMANN-LA ROCHE AG [CH]/[CH] (AL, AT, BE, BG, CH, CN, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IN, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
Inventors
  • JOSHI, Kamal Kishore
  • CARTER, Paul J.
  • YIN, Yiyuan
Agents
  • ONUFRYK, Christina
  • XIAO, Janet
Priority Data
62/845,59409.05.2019US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) METHODS OF MAKING ANTIBODIES
(FR) PROCÉDÉS DE PRÉPARATION D'ANTICORPS
Abstract
(EN)
Provided are, inter alia, methods of improving pairing of a heavy chain and a light chain of an antibody (such as a bispecific antibody). Also provided are antibodies (e.g., bispecific antibodies) generated using such methods, libraries, and methods of screening such libraries.
(FR)
L'invention concerne, entre autres, des procédés d'amélioration de l'appariement d'une chaîne lourde et d'une chaîne légère d'un anticorps (tel qu'un anticorps bispécifique). L'invention concerne également des anticorps (par exemple, des anticorps bispécifiques) générés à l'aide de tels procédés, des bibliothèques et des méthodes de criblage de telles bibliothèques.
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