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1. WO2020227546 - T CELL MANUFACTURING COMPOSITIONS AND METHODS

Publication Number WO/2020/227546
Publication Date 12.11.2020
International Application No. PCT/US2020/031898
International Filing Date 07.05.2020
IPC
A61K 35/28 2015.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35Medicinal preparations containing materials or reaction products thereof with undetermined constitution
12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
28Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
C12N 5/0775 2010.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
5Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
07Animal cells or tissues
071Vertebrate cells or tissues, e.g. human cells or tissues
077Mesenchymal cells, e.g. bone cells, cartilage cells, marrow stromal cells, fat cells or muscle cells
0775Mesenchymal stem cells; Adipose-tissue derived stem cells
Applicants
  • BIONTECH US INC. [US]/[US]
  • STICHTING HET NEDERLANDS KANKER INSTITUUT ANTONI VAN LEEUWENHOEK ZIEKENHUIS [NL]/[NL]
Inventors
  • VAN BUUREN, Marit M.
  • LENKALA, Divya Reddy
  • KOHLER, Jessica
  • BROWN, Flavian Duvalle
  • KUKSIN, Christina Murphy
  • VAN DEN BERG, Joost Huibert
  • DE BOER, Renate
  • BAKKER, Noor
  • SCHUMACHER, Ton
Agents
  • GHOSH, Sanjukta
Priority Data
62/845,25108.05.2019US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) T CELL MANUFACTURING COMPOSITIONS AND METHODS
(FR) COMPOSITIONS ET PROCÉDÉS DE PRODUCTION DE LYMPHOCYTES T
Abstract
(EN)
The generation of antigen specific T cells by controlled ex vivo induction or expansion can provide highly specific and beneficial T cell therapies. The present disclosure provides T cell manufacturing methods and therapeutic T cell compositions which can be used for treating subjects with cancer and other conditions, diseases and disorders personal antigen specific T cell therapy.
(FR)
La génération de lymphocytes T spécifiques à un antigène par l'induction ou l'expansion ex vivo contrôlée peut fournir des thérapies par lymphocytes T hautement spécifiques et bénéfiques. La présente invention concerne des procédés de production de lymphocytes T et des compositions de lymphocytes T thérapeutiques qui peuvent être utilisées pour traiter des sujets atteints d'un cancer et d'autres états, maladies et troubles, au moyen d'une thérapie par lymphocytes T spécifiques à un antigène personnelle.
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