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1. WO2020227446 - ENHANCEMENT OF POLYPEPTIDES AND CHIMERIC ANTIGEN RECEPTORS VIA HINGE DOMAINS

Publication Number WO/2020/227446
Publication Date 12.11.2020
International Application No. PCT/US2020/031728
International Filing Date 06.05.2020
IPC
C07K 14/725 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
705Receptors; Cell surface antigens; Cell surface determinants
725T-cell receptors
C07K 16/28 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18against material from animals or humans
28against receptors, cell surface antigens or cell surface determinants
C07K 19/00 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
19Hybrid peptides
Applicants
  • THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY [US]/[US]
Inventors
  • MAJZNER, Robbie, G.
  • MACKALL, Crystal, L.
  • LABANIEH, Louai
  • RIETBERG, Skyler, P.
Agents
  • DANG, David, V.
  • AZRIN, Linda, B.
  • BAUER, John, A.
  • ADAMS, Lisa
  • AMENDT, Kevin, C.
Priority Data
62/844,68307.05.2019US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) ENHANCEMENT OF POLYPEPTIDES AND CHIMERIC ANTIGEN RECEPTORS VIA HINGE DOMAINS
(FR) AMÉLIORATION DE POLYPEPTIDES ET DE RÉCEPTEURS D'ANTIGÈNES CHIMÉRIQUES PAR L'INTERMÉDIAIRE DE DOMAINES CHARNIÈRES
Abstract
(EN)
The present disclosure generally relates to, inter alia, novel chimeric polypeptides and chimeric antigen receptors (CARs) that include a hinge domain from CD28 and optionally a costimulatory domain not from CD28. The disclosure also provides compositions and methods useful for producing such molecules, as well as methods for the detection and treatment of diseases, such as cancer.
(FR)
De manière générale, la présente invention concerne, entre autres, de nouveaux polypeptides chimériques et des récepteurs d'antigènes chimériques (CAR) qui comprennent un domaine charnière issu de CD28 et éventuellement un domaine de costimulation non issu de CD28. L'invention concerne également des compositions et des procédés utiles pour produire de telles molécules, ainsi que des procédés de détection et de traitement de maladies, telles que le cancer.
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