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1. WO2020226919 - USE OF INHIBITORS OF YAP/TAZ FOR THE TREATMENT OF CANCER

Publication Number WO/2020/226919
Publication Date 12.11.2020
International Application No. PCT/US2020/030001
International Filing Date 26.04.2020
IPC
A61K 39/395 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
A61K 45/06 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
45Medicinal preparations containing active ingredients not provided for in groups A61K31/-A61K41/132
06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
A61P 35/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
A61P 1/04 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1Drugs for disorders of the alimentary tract or the digestive system
04for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
A61P 1/16 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1Drugs for disorders of the alimentary tract or the digestive system
16for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
A61P 25/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
Applicants
  • GEORGETOWN UNIVERSITY [US]/[US]
Inventors
  • YI, Chunling
  • WHITE, Shannon, M.
  • FIELD, Jeffrey
Agents
  • GARMAN, Russell, A.
Priority Data
62/843,55905.05.2019US
62/844,11706.05.2019US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) USE OF INHIBITORS OF YAP/TAZ FOR THE TREATMENT OF CANCER
(FR) UTILISATION D'INHIBITEURS DE YAP/TAZ DANS LE TRAITEMENT DU CANCER
Abstract
(EN)
Methods of treating or preventing cancer, or treating or preventing noncancerous tumors or lesions, in a subject in need thereof. The methods involve administering a therapeutically effective amount of one or more inhibitors of the YAP/TAZ pathway to the subject. In addition, methods of inhibiting or preventing glycolysis in cancer cells in a subject, promoting mitochondrial respiration in cancer cells in a subject, and promoting oxidative stress in cancer cells in a subject, by administering a therapeutically effective amount of one or more inhibitors of the YAP/TAZ pathway to the subject.
(FR)
L'invention concerne des procédés de traitement ou de prévention du cancer, ou de traitement ou de prévention de tumeurs ou de lésions non cancéreuses, chez un sujet en ayant besoin. Les procédés impliquent l'administration d'une quantité thérapeutiquement efficace d'un ou de plusieurs inhibiteurs de la voie YAP/TAZ au sujet. L'invention concerne également des procédés d'inhibition ou de prévention de la glycolyse dans des cellules cancéreuses chez un sujet, favorisant la respiration mitochondriale et le stress oxydatif dans des cellules cancéreuses chez un sujet, par l'administration d'une quantité thérapeutiquement efficace d'un ou de plusieurs inhibiteurs de la voie YAP/TAZ au sujet.
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