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1. WO2020223728 - SUBSTITUTED PYRROLOPYRIDINES AS JAK INHIBITORS

Publication Number WO/2020/223728
Publication Date 05.11.2020
International Application No. PCT/US2020/031332
International Filing Date 04.05.2020
IPC
C07D 239/95 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
239Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
70condensed with carbocyclic rings or ring systems
72Quinazolines; Hydrogenated quinazolines
95with hetero atoms directly attached in positions 2 and 4
C07D 471/04 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
471Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/-C07D463/251
02in which the condensed system contains two hetero rings
04Ortho-condensed systems
C07D 487/04 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
487Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/-C07D477/183
02in which the condensed system contains two hetero rings
04Ortho-condensed systems
CPC
A61K 45/06
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
45Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
A61P 1/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1Drugs for disorders of the alimentary tract or the digestive system
C07D 471/04
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
471Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
02in which the condensed system contains two hetero rings
04Ortho-condensed systems
Applicants
  • ACLARIS THERAPEUTICS, INC. [US]/[US]
Inventors
  • JACOBSEN, Eric Jon
  • ANDERSON, David Randolph
  • BLINN, James Robert
  • MUKHERJEE, Paramita
  • CHANGELIAN, Paul
  • XU, Canxin
Agents
  • FRATTINI, Gregory D.
Priority Data
62/842,19702.05.2019US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) SUBSTITUTED PYRROLOPYRIDINES AS JAK INHIBITORS
(FR) PYRROLOPYRIDINES SUBSTITUÉES EN TANT QU'INHIBITEURS DE JAK
Abstract
(EN)
The present invention relates to new pyrrolopyridine compounds having the structures of Formula (I)-(IV), wherein the R groups, A, B, C, D and n are as defined in the detailed description, and compositions and their application as pharmaceuticals for the treatment of disease. Methods of inhibition of JAK kinase activity in a human or animal subject are also provided for the treatment diseases such as pruritus, alopecia, androgenetic alopecia, alopecia areata, vitiligo and psoriasis.
(FR)
La présente invention concerne de nouveaux composés de pyrrolopyridine ayant les structures de formule (I)-(IV), les groupes R, A, B, C, D et n sont tels que définis dans la description détaillée, et des compositions et leur application en tant que produits pharmaceutiques pour le traitement d'une maladie. L'Invention concerne également des procédés d'inhibition de l'activité de la kinase JAK chez un sujet humain ou animal pour le traitement de maladies telles que le prurit, l'alopécie, la pelade, l'alopécie en aires, le vitiligo et le psoriasis.
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