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1. WO2020223626 - SYSTEMS AND METHODS FOR RATIOMETRIC AND MULTIPLEXED ISOTHERMAL AMPLIFICATION OF NUCLEIC ACIDS

Publication Number WO/2020/223626
Publication Date 05.11.2020
International Application No. PCT/US2020/031011
International Filing Date 01.05.2020
IPC
G01N 21/25 2006.01
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
21Investigating or analysing materials by the use of optical means, i.e. using infra-red, visible or ultra-violet light
17Systems in which incident light is modified in accordance with the properties of the material investigated
25Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
C12Q 1/6844 2018.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
68involving nucleic acids
6844Nucleic acid amplification reactions
G01J 3/02 2006.01
GPHYSICS
01MEASURING; TESTING
JMEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRA-RED, VISIBLE OR ULTRA-VIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
3Spectrometry; Spectrophotometry; Monochromators; Measuring colours
02Details
G01J 3/50 2006.01
GPHYSICS
01MEASURING; TESTING
JMEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRA-RED, VISIBLE OR ULTRA-VIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
3Spectrometry; Spectrophotometry; Monochromators; Measuring colours
46Measurement of colour; Colour measuring devices, e.g. colorimeters
50using electric radiation detectors
G06K 9/00 2006.01
GPHYSICS
06COMPUTING; CALCULATING OR COUNTING
KRECOGNITION OF DATA; PRESENTATION OF DATA; RECORD CARRIERS; HANDLING RECORD CARRIERS
9Methods or arrangements for reading or recognising printed or written characters or for recognising patterns, e.g. fingerprints
G06T 7/90 2017.01
GPHYSICS
06COMPUTING; CALCULATING OR COUNTING
TIMAGE DATA PROCESSING OR GENERATION, IN GENERAL
7Image analysis
90Determination of colour characteristics
Applicants
  • THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY [US]/[US]
Inventors
  • DAS, Rhiju
  • SHIH, Kevin
  • ADRIANOWYCZ, Matthew
Agents
  • HANS, Christian S.
Priority Data
62/841,68901.05.2019US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) SYSTEMS AND METHODS FOR RATIOMETRIC AND MULTIPLEXED ISOTHERMAL AMPLIFICATION OF NUCLEIC ACIDS
(FR) SYSTÈMES ET PROCÉDÉS D'AMPLIFICATION ISOTHERME RATIOMÉTRIQUE ET MULTIPLEXÉE D'ACIDES NUCLÉIQUES
Abstract
(EN)
Systems and methods for isothermal amplification of nucleic acids in a ratiometric manner are disclosed. Methods of isothermal amplification of nucleic acids are convenient for areas that lack reliable electricity and/or funding for precision lab equipment. However, these methods typically result in non-ratiometric amplification of target sequences, thus preventing quantitative analysis or application of the results, such as for diagnostic testing. Systems and methods herein provide a method of isothermal amplification that ratiometrically amplifies target sequences, thus expanding the reach of diagnostics into remote and/or economically disadvantaged areas.
(FR)
La présente invention concerne des systèmes et des procédés d'amplification isotherme d'acides nucléiques d'une manière ratiométrique. Des procédés d'amplification isotherme d'acides nucléiques sont pratiques pour des zones qui manquent d'électricité et/ou de financement fiables pour un équipement de laboratoire de précision. Toutefois, ces procédés conduisent typiquement à une amplification non ratiométrique de séquences cibles, empêchant ainsi une analyse quantitative ou une application des résultats, comme pour un test de diagnostic. Les systèmes et les procédés de l'invention fournissent un procédé d'amplification isotherme qui amplifie de manière ratiométrique des séquences cibles, ce qui permet d'étendre la portée de diagnostics dans des zones distantes et/ou économiquement désavantageuses.
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