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1. WO2020223558 - TRICYCLIC AMINE COMPOUNDS AS CDK2 INHIBITORS


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INTERNATIONAL SEARCH REPORT (ISR)
Part 1:  1  2  3  4  5  6          Part 2:  A  B  C  D  E 
International application No. Applicant's or agent's file reference
PCT/US2020/030851 20443-0607WO1
International filing date (day/month/year) (Earliest) Priority Date (day/month/year)
30 April 2020 01 May 2019
Applicant
INCYTE CORPORATION
FOR FURTHER ACTION: See Form PCT/ISA/220 as well as, where applicable, item 5 below.
This international search report has been prepared by this International Searching Authority and is transmitted to the applicant according to Article 18. A copy is being transmitted to the International Bureau.
It is also accompanied by a copy of each prior art document cited in this report.
1. Basis of the report
a. With regard to the language, the international search was carried out on the basis of:
the international application in the language in which it was filed.
a translation of the international application into                                          which is the language of a translation furnished for the purposes of international search (Rules 12.3(a) and 23.1(b)).
b.
This international search report has been established taking into account the rectification of an obvious mistake authorized by or notified to this Authority under Rule 91 (Rule 43.6bis(a)).
c.
1. With regard to any nucleotide and/or amino acid sequence disclosed in the international application, the international search was carried out on the basis of a sequence listing:
a. forming part of the international application as filed:
in the form of an Annex C/ST.25 text file.
on paper or in the form of an image file.
b. furnished together with the international application under PCT Rule 13ter.1(a) for the purposes of international search only in the form of an Annex C/ST.25 text file.
c. furnished subsequent to the international filing date for the purposes of international search only:
in the form of an Annex C/ST.25 text file (Rule 13ter.1(a)).
on paper or in the form of an image file (Rule 13ter.1(b) and Administrative Instructions, Section 713).
2.
In addition, in the case that more than one version or copy of a sequence listing has been filed or furnished, the required statements that the information in the subsequent or additional copies is identical to that forming part of the application as filed or does not go beyond the application as filed, as appropriate, were furnished.
3.
Additional comments:
2. Certain claims were found unsearchable
3. Unity of invention is lacking
4. Title of the invention
The text is approved as submitted by the applicant.
The text has been established by this Authority to read as follows:
5. Abstract
The text is approved as submitted by the applicant.
The text has been established, according to Rule 38.2, by this Authority as it appears in Box No. IV. The applicant may, within one month from the date of mailing of this international search report, submit comments to this Authority.
6. Drawings
a.
The figure of the drawings to be published with the abstract is Figure No. ____________
as suggested by the applicant.
as selected by this Authority, because the applicant failed to suggest a figure.
as selected by this Authority, because this figure better characterizes the invention.
b.
none of the figures is to be published with the abstract.

A. CLASSIFICATION OF SUBJECT MATTER

     A61P 35/00 (2006.01)i; C07D 487/02 (2006.01)i; C07D 487/14 (2006.01)i; C07D 498/14 (2006.01)i
According to International Patent Classification (IPC) or to both national classification and IPC

B. FIELDS SEARCHED

Minimum documentation searched (classification system followed by classification symbols):
     A61P; C07D
Documentation searched other than minimum documentation to the extent that such documents are included in the fields searched:
Electronic data base consulted during the international search (name of data base and, where practicable, search terms used):
EPO-Internal, CHEM ABS Data, WPI Data

C. DOCUMENTS CONSIDERED TO BE RELEVANT

Category* Citation of document, with indication, where appropriate, of the relevant passages Relevant to claim No.
(1)
A
US 2012220572 A1 (TONG YUNSONG [US] ET AL) 30 August 2012 (2012-08-30)
1-53
abstract
paragraphs [0001] - [0006]
examples 1-361
example 362; table 1
claims 1-20
(2)
Y
WO 2018086591 A1 (SHANGHAI HAIYAN PHARMACEUTICAL TECH CO LTD [CN] ET AL.) 17 May 2018 (2018-05-17)
1-53
abstract
* compounds *;pages 7-9
page 10, lines 20-23
examples 1-65
* table *;pages 45-47
pages 50-51; tables 1-3
claims 1-24
(3)
Y
WO 2018177403 A1 (CHENGDU EUTHARE THERAPEUTICS INC [CN]) 04 October 2018 (2018-10-04)
1-53
abstract
pages 1, 2
pages 25-27
examples 1-77
claims 1-15
(4)
Y
YUNSONG TONG ET AL, "Pyrimidine-Based Tricyclic Molecules as Potent and Orally Efficacious Inhibitors of Wee1 Kinase", ACS MEDICINAL CHEMISTRY LETTERS,Vol. 6, No. 1, 08 January 2015 (2015-01-08), page 58-62,
XP055165188
1-53
abstract
* scheme 1 *;page 59
pages 60-61; tables 1-4
(5)
Y
WO 2018005860 A1 (G1 THERAPEUTICS INC [US]) 04 January 2018 (2018-01-04)
1-53
abstract
* compounds *;pages 147-159
examples 1-6
claims 1-35
(6)
Y
WO 0064900 A1 (HOFFMANN LA ROCHE [CH]) 02 November 2000 (2000-11-02)
1-53
abstract
pages 41-44; tables IA-IC
pages 46-53; tables IIA-IVC
examples 1-8
claims 1-20
(7)
Y
CN 104003988 A (UNIV CHINA PHARMA) 27 August 2014 (2014-08-27)
1-53
abstract
paragraphs [0007] - [0015]
paragraph [0091]
examples 1-55
claims 1-11
*
Special categories of cited documents:
"A"
document defining the general state of the art which is not considered to be of particular relevance
"D"
document cited by the applicant in the international application
"E"
earlier application or patent but published on or after the international filing date
"L"
document which may throw doubts on priority claim(s) or which is cited to establish the publication date of another citation or other special reason (as specified)
"O"
document referring to an oral disclosure, use, exhibition or other means
"P"
document published prior to the international filing date but later than the priority date claimed
"T"
later document published after the international filing date or priority date and not in conflict with the application but cited to understand the principle or theory underlying the invention
"X"
document of particular relevance; the claimed invention cannot be considered novel or cannot be considered to involve an inventive step when the document is taken alone
"Y"
document of particular relevance; the claimed invention cannot be considered to involve an inventive step when the document is combined with one or more other such documents, such combination being obvious to a person skilled in the art
"&"
document member of the same patent family

D. INFORMATION ON PATENT FAMILY MEMBERS

Patent document cited in search report Publication date
(day/month/year)
Patent family member(s) Publication date
(day/month/year)
US 2012220572 A1
30 August 2012
AR 085502 A1
CA 2827648 A1
CN 103703005 A
EP 2681221 A1
ES 2587514 T3
JP 5886326 B2
JP 2014506929 A
MX 340402 B
TW 201247675 A
US 2012220572 A1
UY 33925 A
WO 2012161812 A1
09 October 2013
29 November 2012
02 April 2014
08 January 2014
25 October 2016
16 March 2016
20 March 2014
07 July 2016
01 December 2012
30 August 2012
28 September 2012
29 November 2012
WO 2018086591 A1
17 May 2018
AU 2017356569 A1
CA 3039012 A1
CN 108699067 A
EP 3505519 A1
JP 2020500210 A
US 2020039983 A1
WO 2018086591 A1
18 April 2019
17 May 2018
23 October 2018
03 July 2019
09 January 2020
06 February 2020
17 May 2018
WO 2018177403 A1
04 October 2018
CN 109803972 A
EP 3608321 A1
JP 2020513034 A
KR 20190137843 A
WO 2018177403 A1
24 May 2019
12 February 2020
30 April 2020
11 December 2019
04 October 2018
WO 2018005860 A1
04 January 2018
AU 2017290748 A1
BR 112018077136 A2
CA 3028751 A1
CN 109789143 A
EA 201990187 A1
EP 3478294 A1
JP 2019520379 A
KR 20190025943 A
US 2019135811 A1
WO 2018005860 A1
17 January 2019
30 April 2019
04 January 2018
21 May 2019
31 July 2019
08 May 2019
18 July 2019
12 March 2019
09 May 2019
04 January 2018
WO 0064900 A1
02 November 2000
AR 023542 A1
AT 279413 T
AU 768667 B2
BR 0009887 A
CA 2367704 A1
CN 1348455 A
CN 1603314 A
CO 5170444 A1
CZ 20013738 A3
DE 60014893 T2
DK 1185529 T3
EP 1185529 A1
ES 2228522 T3
HK 1046278 A1
HR P20010742 A2
HU 0300318 A2
JO 2248 B1
JP 3746680 B2
JP 2002543081 A
KR 20010112435 A
MA 26782 A1
NZ 514523 A
PE 20010054 A1
PL 354405 A1
PT 1185529 E
SI 1185529 T1
TR 200103016 T2
TW 585866 B
US 6440959 B1
US 2002183514 A1
US 2004198976 A1
WO 0064900 A1
YU 73101 A
ZA 200108016 B
04 September 2002
15 October 2004
18 December 2003
22 January 2002
02 November 2000
08 May 2002
06 April 2005
27 June 2002
14 August 2002
13 October 2005
07 February 2005
13 March 2002
16 April 2005
12 August 2005
31 December 2002
28 June 2003
07 October 2004
15 February 2006
17 December 2002
20 December 2001
20 December 2004
28 November 2003
07 February 2001
12 January 2004
28 February 2005
28 February 2005
22 April 2002
01 May 2004
27 August 2002
05 December 2002
07 October 2004
02 November 2000
12 May 2004
26 March 2003
CN 104003988 A
27 August 2014
NONE
Name and mailing address of the ISA/:
European Patent Office
P.B. 5818, Patentlaan 2, 2280 HV Rijswijk,
Netherlands
Telephone No. (+31-70)340-2040
Facsimile No. (+31-70)340-3016
Date of the actual completion of the international search:
03 July 2020
Date of mailing of the international search report:
09 July 2020
Authorized officer:
Dunet, Guillaume
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