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1. WO2020223456 - DEGRADATION OF AURORA KINASE (AURK) BY CONJUGATION OF AURK INHIBITORS WITH E3 LIGASE LIGAND

Publication Number WO/2020/223456
Publication Date 05.11.2020
International Application No. PCT/US2020/030663
International Filing Date 30.04.2020
IPC
A61K 31/422 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
41having five-membered rings with two or more ring hetero atoms, at least one of which is nitrogen, e.g. tetrazole
42Oxazoles
422not condensed and containing further heterocyclic rings
A61K 31/427 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
41having five-membered rings with two or more ring hetero atoms, at least one of which is nitrogen, e.g. tetrazole
425Thiazoles
427not condensed and containing further heterocyclic rings
A61K 31/437 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
435having six-membered rings with one nitrogen as the only ring hetero atom
4353ortho- or peri-condensed with heterocyclic ring systems
437the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
Applicants
  • NEMUCORE MEDICAL INNOVATIONS, INC. [US]/[US]
Inventors
  • COLEMAN, Timothy, Patrick
Agents
  • TRINQUE, Brian, C.
  • AREZINA, Vladimir, I.
  • BARTON, Steven, K.
  • ANIS, Hissan
  • CHEN, Xiaoyue (peter)
Priority Data
62/841,36501.05.2019US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) DEGRADATION OF AURORA KINASE (AURK) BY CONJUGATION OF AURK INHIBITORS WITH E3 LIGASE LIGAND
(FR) DÉGRADATION DE L'AURORA KINASE (AURK) PAR CONJUGAISON D'INHIBITEURS DE L'AURK AVEC UN LIGAND DE LIGASE E3
Abstract
(EN)
Provided herein are compounds, which act as protein degradation inducing moieties for aurora kinase (AURK). The present application also relates to methods for the targeted degradation of AURK through the use of the compounds that link a ubiquitin ligase-binding moiety to a ligand that is capable of binding to AURK which can be utilized in the treatment of disorders modulated by AURK.
(FR)
L'invention concerne des composés qui agissent en tant que fractions induisant la dégradation de protéines pour l'aurora kinase (AURK). La présente invention concerne également des procédés pour la dégradation ciblée de l'AURK par l'utilisation des composés qui lient une fraction de liaison à l'ubiquitine ligase à un ligand qui est capable de se lier à l'AURK qui peut être utilisé dans le traitement de troubles modulés par l'AURK.
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