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1. WO2020223267 - (R)-(2-METHYLOXIRAN-2-YL)METHYL 4-BROMOBENZENESULFONATE


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INTERNATIONAL SEARCH REPORT (ISR)
Part 1:  1  2  3  4  5  6          Part 2:  A  B  C  D  E 
International application No. Applicant's or agent's file reference
PCT/US2020/030337 09-0692-WO-1
International filing date (day/month/year) (Earliest) Priority Date (day/month/year)
29 April 2020 01 May 2019
Applicant
BOEHRINGER INGELHEIM INTERNATIONAL GMBH
FOR FURTHER ACTION: See Form PCT/ISA/220 as well as, where applicable, item 5 below.
This international search report has been prepared by this International Searching Authority and is transmitted to the applicant according to Article 18. A copy is being transmitted to the International Bureau.
It is also accompanied by a copy of each prior art document cited in this report.
1. Basis of the report
a. With regard to the language, the international search was carried out on the basis of:
the international application in the language in which it was filed.
a translation of the international application into                                          which is the language of a translation furnished for the purposes of international search (Rules 12.3(a) and 23.1(b)).
b.
This international search report has been established taking into account the rectification of an obvious mistake authorized by or notified to this Authority under Rule 91 (Rule 43.6bis(a)).
c.
With regard to any nucleotide and/or amino acid sequence disclosed in the international application, the international search was carried out on the basis of a sequence listing:
2. Certain claims were found unsearchable
3. Unity of invention is lacking
This International Searching Authority found multiple inventions in this international application, as follows:
1. claims: 1, 12, 14(all partially)
compound of formula I wherein R1 is chloro, namely (R)-2- methyl epichlorohydrin, and matter directed to this compound i.e. process to prepare this compound
2. claims: 3, 13(completely); 1, 12, 14(partially)
compound of formula I wherein R1 is bromo or iodo, and matter directed to this compound i.e. process to prepare this compound
3. claims: 2, 4-11(completely); 1(partially)
compound of formula I wherein R1 is brosylate, and matter directed to this compound i.e. process to prepare this compound
1.
As all required additional search fees were timely paid by the applicant, this international search report covers all searchable claims.
2.
As all searchable claims could be searched without effort justifying additional fees, this Authority did not invite payment of additional fees.
3.
As only some of the required additional search fees were timely paid by the applicant, this international search report covers only those claims for which fees were paid, specifically claims Nos.:
4.
No required additional search fees were timely paid by the applicant. Consequently, this international search report is restricted to the invention first mentioned in the claims; it is covered by claims Nos.: 1, 12, 14(all partially)
Remark on Protest
The additional search fees were accompanied by the applicant’s protest and, where applicable, the payment of a protest fee.
The additional search fees were accompanied by the applicant’s protest but the applicable protest fee was not paid within the time limit specified in the invitation.
No protest accompanied the payment of additional search fees.
4. Title of the invention
The text is approved as submitted by the applicant.
The text has been established by this Authority to read as follows:
5. Abstract
The text is approved as submitted by the applicant.
The text has been established, according to Rule 38.2, by this Authority as it appears in Box No. IV. The applicant may, within one month from the date of mailing of this international search report, submit comments to this Authority.
6. Drawings
a.
The figure of the drawings to be published with the abstract is Figure No. ____________
as suggested by the applicant.
as selected by this Authority, because the applicant failed to suggest a figure.
as selected by this Authority, because this figure better characterizes the invention.
b.
none of the figures is to be published with the abstract.

A. CLASSIFICATION OF SUBJECT MATTER

     C07D 301/19 (2006.01)i; C07D 303/08 (2006.01)i; C07D 303/16 (2006.01)i
According to International Patent Classification (IPC) or to both national classification and IPC

B. FIELDS SEARCHED

Minimum documentation searched (classification system followed by classification symbols):
     C07D
Documentation searched other than minimum documentation to the extent that such documents are included in the fields searched:
Electronic data base consulted during the international search (name of data base and, where practicable, search terms used):
EPO-Internal, WPI Data, CHEM ABS Data

C. DOCUMENTS CONSIDERED TO BE RELEVANT

Category* Citation of document, with indication, where appropriate, of the relevant passages Relevant to claim No.
(1)
X
JP 2007297305 A (DAISO CO LTD) 15 November 2007 (2007-11-15)
1
A
manufacturing example 1 in paragraph 19
12,14
(2)
A
WO 0198273 A1 (ASTRAZENECA AB [SE]; ERIKSSON TOMAS [SE] ET AL.) 27 December 2001 (2001-12-27)
12,14
page 26, lines 10-17
(3)
A
EP 0666256 A1 (TAISHO PHARMA CO LTD [JP]; SATO FUMIE [JP]) 09 August 1995 (1995-08-09)
12,14
page 11, lines 15-22
*
Special categories of cited documents:
"A"
document defining the general state of the art which is not considered to be of particular relevance
"D"
document cited by the applicant in the international application
"E"
earlier application or patent but published on or after the international filing date
"L"
document which may throw doubts on priority claim(s) or which is cited to establish the publication date of another citation or other special reason (as specified)
"O"
document referring to an oral disclosure, use, exhibition or other means
"P"
document published prior to the international filing date but later than the priority date claimed
"T"
later document published after the international filing date or priority date and not in conflict with the application but cited to understand the principle or theory underlying the invention
"X"
document of particular relevance; the claimed invention cannot be considered novel or cannot be considered to involve an inventive step when the document is taken alone
"Y"
document of particular relevance; the claimed invention cannot be considered to involve an inventive step when the document is combined with one or more other such documents, such combination being obvious to a person skilled in the art
"&"
document member of the same patent family

D. INFORMATION ON PATENT FAMILY MEMBERS

Patent document cited in search report Publication date
(day/month/year)
Patent family member(s) Publication date
(day/month/year)
JP 2007297305 A
15 November 2007
NONE
WO 0198273 A1
27 December 2001
AR 028948 A1
AU 7476301 A
AU 2001274763 B2
BR 0111667 A
CA 2414095 A1
CN 1476434 A
CZ 20024146 A3
EE 200200704 A
EP 1299357 A1
HU 0301187 A2
IL 153167 A
IS 6658 A
JP 4022142 B2
JP 2004507461 A
KR 20030017548 A
MX PA02012425 A
MY 136520 A
NO 324698 B1
NZ 523047 A
PL 366198 A1
RU 2298550 C2
SK 17932002 A3
US 2003162772 A1
US 2005090494 A1
US 2009306141 A1
WO 0198273 A1
28 May 2003
02 January 2002
05 October 2006
13 May 2003
27 December 2001
18 February 2004
14 May 2003
16 August 2004
09 April 2003
28 August 2003
15 June 2009
17 December 2002
12 December 2007
11 March 2004
03 March 2003
25 April 2003
31 October 2008
03 December 2007
24 September 2004
24 January 2005
10 May 2007
11 September 2003
28 August 2003
28 April 2005
10 December 2009
27 December 2001
EP 0666256 A1
09 August 1995
AU 669226 B2
CA 2147476 A1
EP 0666256 A1
KR 950703527 A
US 5545666 A
WO 9408959 A1
30 May 1996
28 April 1994
09 August 1995
20 September 1995
13 August 1996
28 April 1994
Name and mailing address of the ISA/:
European Patent Office
P.B. 5818, Patentlaan 2, 2280 HV Rijswijk,
Netherlands
Telephone No. (+31-70)340-2040
Facsimile No. (+31-70)340-3016
Date of the actual completion of the international search:
10 June 2020
Date of mailing of the international search report:
10 August 2020
Authorized officer:
Gutke, Hans-Jürgen
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