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Part 1:  1  2  3  4  5  6          Part 2:  A  B  C  D  E 
International application No. Applicant's or agent's file reference
PCT/US2020/030150 30303/55598/PC
International filing date (day/month/year) (Earliest) Priority Date (day/month/year)
27 April 2020 29 April 2019
FOR FURTHER ACTION: See Form PCT/ISA/220 as well as, where applicable, item 5 below.
This international search report has been prepared by this International Searching Authority and is transmitted to the applicant according to Article 18. A copy is being transmitted to the International Bureau.
It is also accompanied by a copy of each prior art document cited in this report.
1. Basis of the report
a. With regard to the language, the international search was carried out on the basis of:
the international application in the language in which it was filed.
a translation of the international application into                                          which is the language of a translation furnished for the purposes of international search (Rules 12.3(a) and 23.1(b)).
This international search report has been established taking into account the rectification of an obvious mistake authorized by or notified to this Authority under Rule 91 (Rule 43.6bis(a)).
With regard to any nucleotide and/or amino acid sequence disclosed in the international application, the international search was carried out on the basis of a sequence listing:
2. Certain claims were found unsearchable
3. Unity of invention is lacking
4. Title of the invention
The text is approved as submitted by the applicant.
The text has been established by this Authority to read as follows:
5. Abstract
The text is approved as submitted by the applicant.
The text has been established, according to Rule 38.2, by this Authority as it appears in Box No. IV. The applicant may, within one month from the date of mailing of this international search report, submit comments to this Authority.
6. Drawings
The figure of the drawings to be published with the abstract is Figure No.     1A    
as suggested by the applicant.
as selected by this Authority, because the applicant failed to suggest a figure.
as selected by this Authority, because this figure better characterizes the invention.
none of the figures is to be published with the abstract.


     A61K 9/00 (2006.01)i; A61K 31/00 (2006.01)i
According to International Patent Classification (IPC) or to both national classification and IPC


Minimum documentation searched (classification system followed by classification symbols):
Documentation searched other than minimum documentation to the extent that such documents are included in the fields searched:
Electronic data base consulted during the international search (name of data base and, where practicable, search terms used):
EPO-Internal, WPI Data


Category* Citation of document, with indication, where appropriate, of the relevant passages Relevant to claim No.
WO 2016209555 A1 (ALLGENESIS BIOTHERAPEUTICS INC; NGUYEN TAN [US]) 29 December 2016 (2016-12-29)
the whole document
claims 1-15; examples 1-5
WO 2013166436 A1 (KALA PHARMACEUTICALS INC [US]) 07 November 2013 (2013-11-07)
the whole document
claims 1-91
WO 2019051084 A1 (REVOLUTION MEDICINES INC [US]) 14 March 2019 (2019-03-14)
the whole document
claims 1-147
Special categories of cited documents:
document defining the general state of the art which is not considered to be of particular relevance
document cited by the applicant in the international application
earlier application or patent but published on or after the international filing date
document which may throw doubts on priority claim(s) or which is cited to establish the publication date of another citation or other special reason (as specified)
document referring to an oral disclosure, use, exhibition or other means
document published prior to the international filing date but later than the priority date claimed
later document published after the international filing date or priority date and not in conflict with the application but cited to understand the principle or theory underlying the invention
document of particular relevance; the claimed invention cannot be considered novel or cannot be considered to involve an inventive step when the document is taken alone
document of particular relevance; the claimed invention cannot be considered to involve an inventive step when the document is combined with one or more other such documents, such combination being obvious to a person skilled in the art
document member of the same patent family


Patent document cited in search report Publication date
Patent family member(s) Publication date
WO 2016209555 A1
29 December 2016
AU 2016283517 A1
BR 112017025757 A2
CA 2989121 A1
CN 107708664 A
EP 3310339 A1
JP 6680807 B2
JP 2018524327 A
KR 20170140399 A
KR 20200018714 A
TW 201703770 A
TW 201936187 A
US 2017368061 A1
US 2018243294 A1
WO 2016209555 A1
14 December 2017
14 August 2018
29 December 2016
16 February 2018
25 April 2018
15 April 2020
30 August 2018
20 December 2017
19 February 2020
01 February 2017
16 September 2019
28 December 2017
30 August 2018
29 December 2016
WO 2013166436 A1
07 November 2013
AU 2013256092 A1
AU 2018201215 A1
AU 2020203052 A1
BR 112014027296 A2
CA 2871748 A1
CL 2014002956 A1
CL 2019003432 A1
CL 2019003433 A1
CN 104661647 A
EP 2844223 A1
HK 1208161 A1
HK 1208382 A1
JP 6720443 B2
JP 2015519331 A
JP 2020015758 A
KR 20150006869 A
NZ 700875 A
NZ 728721 A
NZ 741873 A
NZ 742004 A
NZ 742005 A
US 2013316001 A1
US 2013316006 A1
US 2018271782 A1
WO 2013166436 A1
30 October 2014
08 March 2018
28 May 2020
18 July 2017
07 November 2013
02 October 2015
08 May 2020
08 May 2020
27 May 2015
11 March 2015
26 February 2016
04 March 2016
08 July 2020
09 July 2015
30 January 2020
19 January 2015
31 March 2017
25 May 2018
26 April 2019
26 April 2019
26 April 2019
28 November 2013
28 November 2013
27 September 2018
07 November 2013
WO 2019051084 A1
14 March 2019
AU 2018328273 A1
CA 3074690 A1
CN 111344017 A
CO 2020002588 A2
EP 3678703 A1
KR 20200051684 A
SG 11202001282U A
TW 201918260 A
WO 2019051084 A1
12 March 2020
14 March 2019
26 June 2020
19 June 2020
15 July 2020
13 May 2020
30 March 2020
16 May 2019
14 March 2019
Name and mailing address of the ISA/:
European Patent Office
P.B. 5818, Patentlaan 2, 2280 HV Rijswijk,
Telephone No. (+31-70)340-2040
Facsimile No. (+31-70)340-3016
Date of the actual completion of the international search:
13 July 2020
Date of mailing of the international search report:
21 July 2020
Authorized officer:
Felder, Christian
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