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1. WO2020223177 - MEK INHIBITORS FOR CORNEAL SCARRING AND NEOVASCULARIZATION

Publication Number WO/2020/223177
Publication Date 05.11.2020
International Application No. PCT/US2020/030150
International Filing Date 27.04.2020
IPC
A61K 9/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
A61K 31/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
CPC
A61K 31/166
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
16Amides, e.g. hydroxamic acids
165having aromatic rings, e.g. colchicine, atenolol, progabide
166having the carbon of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
A61K 31/18
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
16Amides, e.g. hydroxamic acids
18Sulfonamides
A61K 31/4523
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
435having six-membered rings with one nitrogen as the only ring hetero atom
44Non condensed pyridines; Hydrogenated derivatives thereof
445Non condensed piperidines, e.g. piperocaine
4523containing further heterocyclic ring systems
A61K 9/0048
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
0012Galenical forms characterised by the site of application
0048Eye, e.g. artificial tears
Applicants
  • THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS [US]/[US]
Inventors
  • DJALILIAN, Ali, R.
Agents
  • SINTICH, Sharon, M.
Priority Data
62/840,06929.04.2019US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) MEK INHIBITORS FOR CORNEAL SCARRING AND NEOVASCULARIZATION
(FR) INHIBITEURS DE MEK POUR LA CICATRISATION DE LA CORNÉE ET LA NÉOVASCULARISATION
Abstract
(EN)
The present disclosure relates to ophthalmic compositions and methods for inducing PAX6 expression in a cells and for reducing or preventing corneal scarring, corneal neovascularization and/or corneal opacification. The disclosure also provide for ophthalmic compositions and methods for improving vision or reducing limitations on vision.
(FR)
La présente invention concerne des compositions ophtalmiques et des procédés pour induire l'expression de PAX6 dans des cellules et pour réduire ou prévenir une formation de cicatrice cornéenne, une néovascularisation cornéenne et/ou une opacification de la cornée. L'invention concerne également des compositions ophtalmiques et des procédés pour améliorer la vision ou réduire les limitations de la vision.
Latest bibliographic data on file with the International Bureau