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1. WO2020222666 - USE OF A CHIRAL 2-AZABICYCLOALKANE DERIVATIVE WITH DANSYL SUBSTITUENT AS VP24 PROTEASE INHIBITOR TO INHIBIT THE REPLICATION OF HSV-1 VIRUS

Publication Number WO/2020/222666
Publication Date 05.11.2020
International Application No. PCT/PL2020/050034
International Filing Date 24.04.2020
IPC
A61K 31/55 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
55having seven-membered rings, e.g. azelastine, pentylenetetrazole
A61P 31/22 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
12Antivirals
20for DNA viruses
22for herpes viruses
CPC
A61K 31/55
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
55having seven-membered rings, e.g. azelastine, pentylenetetrazole
A61P 31/22
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
12Antivirals
20for DNA viruses
22for herpes viruses
Applicants
  • POLITECHNIKA WROCŁAWSKA [PL]/[PL]
  • UNIWERSYTET JAGIELLOŃSKI [PL]/[PL]
Inventors
  • WOJACZYŃSKA, Elżbieta
  • IWAN, Dominika
  • GRZYWA, Renata
  • SIEŃCZYK, Marcin
  • PYRĆ, Krzysztof
  • PACHOTA, Magdalena
Agents
  • WINOHRADNIK, Halina Józefa
Priority Data
P.42977829.04.2019PL
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) USE OF A CHIRAL 2-AZABICYCLOALKANE DERIVATIVE WITH DANSYL SUBSTITUENT AS VP24 PROTEASE INHIBITOR TO INHIBIT THE REPLICATION OF HSV-1 VIRUS
(FR) UTILISATION D'UN DÉRIVÉ DE 2-AZABICYCLOALCANE CHIRAL AVEC UN SUBSTITUANT DANSYLE EN TANT QU'INHIBITEUR DE PROTÉASE VP24 POUR INHIBER LA RÉPLICATION DU VIRUS HSV-1
Abstract
(EN)
The subject of the invention is the use of a chiral 2-azabicycloalkane derivative with dansyl substituent as VP24 protease inhibitor to inhibit the replication of HSV-1 virus. The invention concerns chiral 2-azabicycloalkane derivative with dansyl substituent, formula 1, for use as a drug especially for the treatment and prevention of herpes type 1 by inhibiting the replication of HSV-1 virus.
(FR)
L'invention a pour objet l'utilisation d'un dérivé de 2-azabicycloalcane chiral avec un substituant dansyle en tant qu'inhibiteur de la protéase VP24 pour inhiber la réplication du virus HSV-1. L'invention concerne un dérivé de 2-azabicycloalcane chiral avec un substituant dansyle, de formule 1, destiné à être utilisé en tant que médicament, en particulier pour le traitement et la prévention de l'herpès de type 1 par inhibition de la réplication du virus HSV-1.
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