Processing

Please wait...

Settings

Settings

Goto Application

1. WO2020222259 - SYNERGISTIC HERBAL COMPOSITIONS FOR SARCOPENIA

Note: Text based on automatic Optical Character Recognition processes. Please use the PDF version for legal matters

[ EN ]

We Claim,

1. A synergistic herbal composition comprising at least two herbal ingredients selected from the extract(s), fiaction(s), phytochemical(s) and mixtures thereof derived from Syzygium cumini, Rubia cordifolia and Mangifera indica for obtaining at least one health benefit selected from treating/alleviating sarcopenia, preventing muscle loss, improving muscle mass, improving exercise performance, stimulating muscle protein synthesis and improving recovery of muscle functionality after muscle atrophy.

2. The synergistic composition as claimed in claim 1, wherein the concentration of the first ingredient selected from Syzygium cumini, Rubia cordifolia and Mangifera indica in the composition varies in the range of 10%-90% by weight and the concentration of the second ingredient selected from Syzygium cumini, Rubia cordifolia and Mangifera indica varies in the range of 90%-10% by weight.

3. The synergistic composition as claimed in claim 1, wherein the concentration of extract, fraction, phytochemical and mixtures thereof derived from Rubia cordifolia in the composition varies in the range of 10%-90% by weight and concentration of the extract, fraction, phytochemical and mixtures thereof derived from Mangifera indica in the composition varies in the range of 10%-90% by weight.

4. The synergistic composition as claimed in claim 1, wherein the concentration of extract, fraction, phytochemical and mixtures thereof derived from Syzygium cumini in the composition varies in the range of 10%-90% by weight and concentration of the extract, fraction, phytochemical and mixtures thereof derived from Mangifera indica in the composition varies in the range of 10%-90% by weight.

5. The synergistic composition as claimed in claim 1, wherein the concentration of extract, fraction, phytochemical and mixtures thereof derived from Syzygium cumini in the composition varies in the range of 10%-90% by weight and concentration of the extract, fraction, phytochemical and mixtures thereof derived from Rubia cordifolia in the composition varies in the range of 10%-90% by weight.

6. The synergistic composition as claimed in claim 1, wherein the compositions are standardized to at least one phytochemical reference marker compound or biological active marker in the extract or fraction; wherein the concentration of phytochemical marker compound or group of phytochemical compounds is in the range of 0.1% to 99% by weight of the composition.

7. The synergistic composition as claimed in any one of the claims 1 to 3 and 6, wherein the said compositions are standardized to at least one phytochemical compound of Rubia cordifolia, which include but not limited to Munjistin (Manjistin), Rubiadin and 2-methyl- 1,3, 6-trihydroxy- 9, 10-anthraquinone-3 -O-(6'-O-acetyl)-a-rhamnosyl-( 1 -2)-b-glucoside ; wherein the phytochemical is in the concentration range of 0.05% to 10% by weight of the composition.

8. The synergistic composition as claimed in any one of the claims 1 to 4 and 6, wherein the said compositions are standardized to at least one phytochemical compound of Mangifera indica, which include but not limited to Pentagalloyl glucose; wherein the Pentagalloyl glucose is in the concentration range of 0.05% to 10% by weight of the composition.

9. The synergistic composition as claimed in claim 1, wherein the extract, fraction or phytochemical is obtained from at least one plant part selected from the group comprising leaves, stems, tender stems, tender twigs, aerial parts, whole fruit, fruit peel rind, seed, seed kernel, flower heads, root, bark, hardwood, rhizome or whole plant or mixtures thereof.

10. The synergistic composition as claimed in claim 1, wherein the extract, fraction or phytochemical is produced using at least one solvent selected from the group comprising C1-C5 alcohols like ethanol, methanol, n- propanol, isopropyl alcohol; ketones like acetone, methyl isobutyl ketone; chlorinated solvents like methylene dichloride and chloroform; C1-C7

hydrocarbons such as hexane; esters like ethyl acetate; water and mixtures thereof.

11. The synergistic composition as claimed in claim 1, wherein the synergistic compositions optionally containing at least one component selected from pharmaceutically or nutraceutically or dietically acceptable excipients, carriers and diluents.

12. The synergistic composition as claimed in claim 11, wherein the pharmaceutically or nutraceutically or dietically acceptable excipients, carriers and diluents are selected from monosaccharide’s such as glucose, dextrose, fructose, galactose etc.; Disaccharides such as but not limited to sucrose, maltose, lactose, lactulose, trehalose, cellobiose, chitobiose etc.; Polycarbohydrates such as Starch and modified starch such as Sodium starch glycolate, pre-gelatinized starch, soluble starch, and other modified starches; Dextrins that are produced by hydrolysis of starch or glycogen such as yellow dextrin, white dextrin, Maltodextrin etc.; Polyhydric alcohols or sugar alcohols such as but not limited to Sorbitol, mannitol, inositol, xylitol, isomalt etc.; cellulose based derivatives such as but not limited to microcrystalline cellulose, hydroxy propyl methyl cellulose, hydroxy ethyl cellulose etc.; silicates such as but not limited to neusilin, veegum, Talc, colloidal silicon dioxide etc.; metallic stearates such as but not limited to calcium stearate, magnesium stearate, zinc Stearate etc.; Organic acids such as citric acid, tartaric acid, malic acid, succinic acid, lactic acid, L-ascorbic acid etc.; Fatty acid esters and esters of poly sorbate, natural gums such as but not limited to acacia, carrageenan, Guar gum, Xanthan gum etc.; vitamin B group, nicotinamide, calcium pantothenate, amino acids, proteins such as but not limited to casein, gelatin, pectin, agar; organic metal salts such as but not limited to sodium chloride, calcium chloride, dicalcium phosphate, zinc Sulphate, zinc chloride etc.; Natural pigments, flavors, Class I & Class P preservatives and aqueous, alcoholic, hydro-alcoholic, organic solutions of above listed ingredients alone or in combination.

13. The synergistic composition as claimed in any one of the preceding claims 1 to 12, where in the composition(s) are formulated into a dosage form selected from dry powder form, liquid form, beverage, water dispersible formulation, food product, dietary supplement or any suitable form such as a tablet, a capsule, a soft chewable or gummy bear.

14. The synergistic composition as claimed in any one of the preceding claims 1 to 13, where in the compositions are formulated into nutritional/dietary supplements that can be contemplated/made into the dosage form of healthy foods, or food for specified health uses such as solid food like chocolate or nutritional bars, water dispersible beverage, semisolid food like cream, jam, or gel or beverage such as refreshing beverage, lactic acid bacteria beverage, drop, candy, chewing gum, gummy candy, yoghurt, ice cream, pudding, soft adzuki bean jelly, jelly, cookie, tea, soft drink, juice, milk, coffee, cereal, snack bar and the like.

15. A method of obtaining at least one health benefit selected from treating/alleviating sarcopenia, preventing muscle loss, improving muscle mass, improving exercise performance, stimulating muscle protein synthesis and improving recovery of muscle functionality after muscle atrophy, wherein the method comprises supplementing the human in need with an effective dose of a composition comprising at least two herbal ingredients selected from the extract(s), fraction(s), phytochemical(s) and mixtures thereof derived from Syzygium cumini, Rubia cordifolia and Mangifera indica; and optionally containing at least one component selected from pharmaceutically or nutraceutically or dietically acceptable excipients, carriers and diluents.

16. The method as claimed in claim 15, wherein supplementing the human or animal with a suitable dose is in the form of tablets, capsules, controlled release tablets or using controlled release polymer-based coatings by the techniques including nanotechnology, microencapsulation, colloidal carrier systems and other drug delivery systems for obtaining the desired therapeutic benefit.

17. Use of synergistic herbal compositions comprising at least two herbal ingredients selected from the extract(s), fiaction(s), phytochemical(s) and mixtures thereof derived from Syzygium cumini, Rubia cordifolia and Mangifera indica; and optionally containing at least one component selected from pharmaceutically or nutraceutically or dietically acceptable excipients, carriers and diluents for obtaining at least one health benefit selected from treating/alleviating sarcopenia, preventing muscle loss, improving muscle mass, improving exercise performance, stimulating muscle protein synthesis and improving recovery of muscle functionality after muscle atrophy.