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1. WO2020222256 - POLYMORPHS OF 7-CYCLOPENTYL-N,N-DIMETHYL-2-{[5-(PIPERAZIN-1-YL) PYRIDIN-2-YL]-AMINO}-7H-PYRROLO[2,3-D]PYRIMIDINE-6-CARBOXAMIDE AND ITS PHARMACEUTICALLY ACCEPTABLE SALTS AND PROCESS FOR THE PREPARATION THEREOF

Publication Number WO/2020/222256
Publication Date 05.11.2020
International Application No. PCT/IN2020/050391
International Filing Date 29.04.2020
IPC
A61K 31/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
C07D 487/04 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
487Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/-C07D477/183
02in which the condensed system contains two hetero rings
04Ortho-condensed systems
C07D 401/14 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
401Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
14containing three or more hetero rings
Applicants
  • MSN LABORATORIES PRIVATE LIMITED, R&D CENTER [IN]/[IN]
  • SRINIVASAN, Thirumalai Rajan [IN]/[IN]
Inventors
  • SRINIVASAN, Thirumalai Rajan
  • SAJJA, Eswaraiah
  • REVU, Satyanarayana
  • SAGYAM, Rajeshwar Reddy
  • RANGINENI, Srinivasulu
  • SRINIVASAN, Ravichandran
  • SALADI, Venkata Narasayya
  • RAGAM, Naveen
Priority Data
20194101693429.04.2019IN
20194102843815.07.2019IN
20194103202307.08.2019IN
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) POLYMORPHS OF 7-CYCLOPENTYL-N,N-DIMETHYL-2-{[5-(PIPERAZIN-1-YL) PYRIDIN-2-YL]-AMINO}-7H-PYRROLO[2,3-D]PYRIMIDINE-6-CARBOXAMIDE AND ITS PHARMACEUTICALLY ACCEPTABLE SALTS AND PROCESS FOR THE PREPARATION THEREOF
(FR) POLYMORPHES DE 7-CYCLOPENTYL-N,N-DIMÉTHYL-2-{[5-(PIPÉRAZIN-1-YL)PYRIDIN-2-YL]-AMINO}-7H-PYRROLO[2,3-D]PYRIMIDINE-6-CARBOXAMIDE ET DE SES SELS DE QUALITÉ PHARMACEUTIQUE ET LEUR PROCÉDÉ DE PRÉPARATION
Abstract
(EN)
The present invention relates to novel crystalline forms of butanedioic acid 7-cyclopentyl-N,N-dimethyl-2-{[5-(piperazin-1-yl) pyridin-2-yl]amino}-7H-pyrrolo[2,3-d] pyrimidine-6-carboxamide of formula-1a and process for preparation thereof. The present invention also relates to a process for the preparation of 7-cyclopentyl-N,N-dimethyl-2-{[5-(piperazin-1-yl)pyridin-2-yl]amino}-7H-pyrrolo[2,3-d] pyrimidine-6-carboxamide. Further, the present application also relates to acid addition salts of 7-cyclopentyl-N,N-dimethyl-2-{[5-(piperazin-1-yl)pyridin-2-yl]amino}-7H-pyrrolo[2,3-d] pyrimidine-6-carboxamide and process for the preparation thereof.
(FR)
La présente invention concerne de nouvelles formes cristallines de l'acide butanedioïque 7-cyclopentyl-N,N-diméthyl-2-{[5-(pipérazin-1-yl)pyridin-2-yl]amino}-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide de formule 1a et leur procédé de préparation. La présente invention concerne également un procédé de préparation de 7-cyclopentyl-N,N-diméthyl-2-{[5-(pipérazin-1-yl)pyridin-2-yl]amino}-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide. En outre, la présente invention concerne également des sels d'addition acide du 7-cyclopentyl-N,N-diméthyl-2-{[5-(pipérazin-1-yl)pyridin-2-yl] amino}-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide et leur procédé de préparation.
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