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1. WO2020222256 - POLYMORPHS OF 7-CYCLOPENTYL-N,N-DIMETHYL-2-{[5-(PIPERAZIN-1-YL) PYRIDIN-2-YL]-AMINO}-7H-PYRROLO[2,3-D]PYRIMIDINE-6-CARBOXAMIDE AND ITS PHARMACEUTICALLY ACCEPTABLE SALTS AND PROCESS FOR THE PREPARATION THEREOF

Publication Number WO/2020/222256
Publication Date 05.11.2020
International Application No. PCT/IN2020/050391
International Filing Date 29.04.2020
IPC
A61K 31/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
C07D 487/04 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
487Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/-C07D477/183
02in which the condensed system contains two hetero rings
04Ortho-condensed systems
C07D 401/14 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
401Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
14containing three or more hetero rings
CPC
C07C 55/10
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
55Saturated compounds having more than one carboxyl group bound to acyclic carbon atoms
02Dicarboxylic acids
10Succinic acid
C07D 213/74
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
213Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
02having three double bonds between ring members or between ring members and non-ring members
04having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
60with heteroatoms or with carbon atoms having three bonds to hetero atoms, with at the most one to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
72Nitrogen atoms
74Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
C07D 487/04
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
487Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by C07D451/00 - C07D477/00
02in which the condensed system contains two hetero rings
04Ortho-condensed systems
Applicants
  • MSN LABORATORIES PRIVATE LIMITED, R&D CENTER [IN]/[IN]
  • SRINIVASAN, Thirumalai Rajan [IN]/[IN]
Inventors
  • SRINIVASAN, Thirumalai Rajan
  • SAJJA, Eswaraiah
  • REVU, Satyanarayana
  • SAGYAM, Rajeshwar Reddy
  • RANGINENI, Srinivasulu
  • SRINIVASAN, Ravichandran
  • SALADI, Venkata Narasayya
  • RAGAM, Naveen
Priority Data
20194101693429.04.2019IN
20194102843815.07.2019IN
20194103202307.08.2019IN
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) POLYMORPHS OF 7-CYCLOPENTYL-N,N-DIMETHYL-2-{[5-(PIPERAZIN-1-YL) PYRIDIN-2-YL]-AMINO}-7H-PYRROLO[2,3-D]PYRIMIDINE-6-CARBOXAMIDE AND ITS PHARMACEUTICALLY ACCEPTABLE SALTS AND PROCESS FOR THE PREPARATION THEREOF
(FR) POLYMORPHES DE 7-CYCLOPENTYL-N,N-DIMÉTHYL-2-{[5-(PIPÉRAZIN-1-YL)PYRIDIN-2-YL]-AMINO}-7H-PYRROLO[2,3-D]PYRIMIDINE-6-CARBOXAMIDE ET DE SES SELS DE QUALITÉ PHARMACEUTIQUE ET LEUR PROCÉDÉ DE PRÉPARATION
Abstract
(EN)
The present invention relates to novel crystalline forms of butanedioic acid 7-cyclopentyl-N,N-dimethyl-2-{[5-(piperazin-1-yl) pyridin-2-yl]amino}-7H-pyrrolo[2,3-d] pyrimidine-6-carboxamide of formula-1a and process for preparation thereof. The present invention also relates to a process for the preparation of 7-cyclopentyl-N,N-dimethyl-2-{[5-(piperazin-1-yl)pyridin-2-yl]amino}-7H-pyrrolo[2,3-d] pyrimidine-6-carboxamide. Further, the present application also relates to acid addition salts of 7-cyclopentyl-N,N-dimethyl-2-{[5-(piperazin-1-yl)pyridin-2-yl]amino}-7H-pyrrolo[2,3-d] pyrimidine-6-carboxamide and process for the preparation thereof.
(FR)
La présente invention concerne de nouvelles formes cristallines de l'acide butanedioïque 7-cyclopentyl-N,N-diméthyl-2-{[5-(pipérazin-1-yl)pyridin-2-yl]amino}-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide de formule 1a et leur procédé de préparation. La présente invention concerne également un procédé de préparation de 7-cyclopentyl-N,N-diméthyl-2-{[5-(pipérazin-1-yl)pyridin-2-yl]amino}-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide. En outre, la présente invention concerne également des sels d'addition acide du 7-cyclopentyl-N,N-diméthyl-2-{[5-(pipérazin-1-yl)pyridin-2-yl] amino}-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide et leur procédé de préparation.
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