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1. WO2020222146 - INHALER SYSTEM

Publication Number WO/2020/222146
Publication Date 05.11.2020
International Application No. PCT/IB2020/054056
International Filing Date 30.04.2020
IPC
G16H 50/30 2018.01
GPHYSICS
16INFORMATION AND COMMUNICATION TECHNOLOGY SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
HHEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
50ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics
30for calculating health indices; for individual health risk assessment
A61M 15/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
15Inhalators
A61B 5/087 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
BDIAGNOSIS; SURGERY; IDENTIFICATION
5Measuring for diagnostic purposes; Identification of persons
08Measuring devices for evaluating the respiratory organs
087Measuring breath flow
G16H 20/13 2018.01
GPHYSICS
16INFORMATION AND COMMUNICATION TECHNOLOGY SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
HHEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
20ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance
10relating to drugs or medications, e.g. for ensuring correct administration to patients
13delivered from dispensers
CPC
A61B 5/087
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
BDIAGNOSIS; SURGERY; IDENTIFICATION
5Detecting, measuring or recording for diagnostic purposes
08Detecting, measuring or recording devices for evaluating the respiratory organs
087Measuring breath flow
A61B 5/4839
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
BDIAGNOSIS; SURGERY; IDENTIFICATION
5Detecting, measuring or recording for diagnostic purposes
48Other medical applications
4836Diagnosis combined with treatment in closed-loop systems or methods
4839combined with drug delivery
A61B 5/4842
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
BDIAGNOSIS; SURGERY; IDENTIFICATION
5Detecting, measuring or recording for diagnostic purposes
48Other medical applications
4842Monitoring progression or stage of a disease
A61B 5/74
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
BDIAGNOSIS; SURGERY; IDENTIFICATION
5Detecting, measuring or recording for diagnostic purposes
74Details of notification to user or communication with user or patient
A61K 9/0073
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
0012Galenical forms characterised by the site of application
007Pulmonary tract; Aromatherapy
0073Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy;
A61M 15/0026
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY
15Inhalators
0001Details of inhalators; Constructional features thereof
0021Mouthpieces therefor
0025with caps
0026Hinged caps
Applicants
  • NORTON (WATERFORD) LIMITED [IE]/[IE]
Inventors
  • MILTON-EDWARDS, Mark
  • SAFIOTI, Guilherme
  • GRANOVSKY, Lena
  • REICH, Michael
Agents
  • ELKINGTON AND FIFE LLP
Priority Data
1906078.930.04.2019GB
1910776.229.07.2019GB
1919070.120.12.2019GB
1919076.820.12.2019GB
1919081.820.12.2019GB
2003534.111.03.2020GB
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) INHALER SYSTEM
(FR) SYSTÈME D'INHALATEUR
Abstract
(EN)
Provided is a system (10) for determining a probability of an asthma exacerbation in a subject. The system comprises a first inhaler (100) for delivering a rescue medicament to the subject. The rescue medicament may be suitable for treating the subject's acute respiratory disease, for example by effecting rapid dilation of the bronchi and bronchioles upon inhalation of the medicament. The first inhaler has a use-detection system (12B) configured to determine a rescue inhalation performed by the subject using the first inhaler. The system optionally includes a second inhaler for delivering a maintenance medicament to the subject during a routine inhalation. A sensor system (12A) is configured to measure a parameter relating to airflow during the rescue inhalation and/or during the routine inhalation, when the second inhaler is included in the system. The system further comprises a processor (14) configured to determine a number of the rescue inhalations during a first time period, and receive the parameter measured for at least some of the rescue and/or routine inhalations. The processor then determines, using a weighted model, the probability of the asthma exacerbation based on the number of rescue inhalations and the parameters. The model is weighted such that the number of rescue inhalations is more significant in the probability determination than the parameters. Further provided is a method for determining the probability of an asthma exacerbation in a subject, which method employs the weighted model.
(FR)
L'invention concerne un système (10) pour déterminer une probabilité d'une exacerbation de l'asthme chez un sujet. Le système comprend un premier inhalateur (100) pour administrer un médicament de secours au sujet. Le médicament de secours peut être approprié pour traiter la maladie respiratoire aiguë du sujet, par exemple en effectuant une dilatation rapide des bronches et des bronchioles lors de l'inhalation du médicament. Le premier inhalateur comprend un système de détection d'utilisation (12B) configuré pour déterminer une inhalation de secours effectuée par le sujet à l'aide du premier inhalateur. Le système comprend éventuellement un second inhalateur pour administrer un médicament de maintenance au sujet pendant une inhalation de routine. Un système de capteur (12A) est configuré pour mesurer un paramètre relatif à l'écoulement d'air pendant l'inhalation de secours et/ou pendant l'inhalation de routine, lorsque le second inhalateur est inclus dans le système. Le système comprend en outre un processeur (14) configuré pour déterminer un certain nombre des inhalations de secours pendant une première période de temps, et recevoir le paramètre mesuré pour au moins certaines des inspirations de secours et/ou de routine. Le processeur détermine ensuite, à l'aide d'un modèle pondéré, la probabilité de l'exacerbation de l'asthme sur la base du nombre d'inhalations de secours et des paramètres. Le modèle est pondéré de telle sorte que le nombre d'inhalations de secours est plus significatif dans la détermination de probabilité que les paramètres. L'invention concerne en outre un procédé pour déterminer la probabilité d'une exacerbation de l'asthme chez un sujet, lequel procédé utilise le modèle pondéré.
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