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1. WO2020221769 - SCREENING METHODS AND ASSAYS FOR USE WITH TRANSMEMBRANE PROTEINS, IN PARTICULAR WITH GPCRS

Publication Number WO/2020/221769
Publication Date 05.11.2020
International Application No. PCT/EP2020/061803
International Filing Date 28.04.2020
IPC
G01N 33/566 2006.01
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48Biological material, e.g. blood, urine; Haemocytometers
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53Immunoassay; Biospecific binding assay; Materials therefor
566using specific carrier or receptor proteins as ligand binding reagent
C07K 14/705 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
705Receptors; Cell surface antigens; Cell surface determinants
C07K 14/72 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
705Receptors; Cell surface antigens; Cell surface determinants
72for hormones
CPC
C07K 14/705
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
705Receptors; Cell surface antigens; Cell surface determinants
C07K 14/723
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
705Receptors; Cell surface antigens; Cell surface determinants
72for hormones
723G protein coupled receptor, e.g. TSHR-thyrotropin-receptor, LH/hCG receptor, FSH receptor
C07K 2319/74
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
2319Fusion polypeptide
70containing domain for protein-protein interaction
74containing a fusion for binding to a cell surface receptor
G01N 2333/726
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
2333Assays involving biological materials from specific organisms or of a specific nature
435from animals; from humans
705Assays involving receptors, cell surface antigens or cell surface determinants
72for hormones
726G protein coupled receptor, e.g. TSHR-thyrotropin-receptor, LH/hCG receptor, FSH
G01N 2500/04
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
2500Screening for compounds of potential therapeutic value
04Screening involving studying the effect of compounds C directly on molecule A (e.g. C are potential ligands for a receptor A, or potential substrates for an enzyme A)
G01N 33/566
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
48Biological material, e.g. blood, urine
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53Immunoassay; Biospecific binding assay; Materials therefor
566using specific carrier or receptor proteins as ligand binding reagents ; where possible specific carrier or receptor proteins are classified with their target compounds
Applicants
  • CONFO THERAPEUTICS N.V. [BE]/[BE]
Inventors
  • MENET, Christel
  • DEKEYZER, Lies
  • MARTINI, Murielle
  • SKIETERSKA, Kamila
Agents
  • NEDERLANDSCH OCTROOIBUREAU
Priority Data
62/840,09129.04.2019US
62/840,09229.04.2019US
62/840,09429.04.2019US
62/863,54419.06.2019US
62/934,13312.11.2019US
62/934,13612.11.2019US
62/934,18112.11.2019US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) SCREENING METHODS AND ASSAYS FOR USE WITH TRANSMEMBRANE PROTEINS, IN PARTICULAR WITH GPCRS
(FR) PROCÉDÉS DE CRIBLAGE ET DOSAGES DESTINÉS À ÊTRE UTILISÉS AVEC DES PROTÉINES TRANSMEMBRANAIRES, EN PARTICULIER AVEC DES GPCR
Abstract
(EN)
The invention provides methods and arrangements for screening membrane proteins. The arrangement comprises a first fusion protein comprising a membrane protein present in a boundary layer such as a wall of a cell, liposome or vesicle fused to one member of a binding pair and a second fusion protein comprising an intracellular ligand of said membrane protein fused to another member of the binding pair, in which the binding pair is capable of generating a detectable signal.
(FR)
L'invention concerne des procédés et des agencements pour cribler des protéines membranaires. L'agencement comprend une première protéine de fusion comprenant une protéine membranaire présente dans une couche limite telle qu'une paroi d'une cellule, liposome ou vésicule fusionnée à un élément d'une paire de liaison et une seconde protéine de fusion comprenant un ligand intracellulaire de ladite protéine membranaire fusionnée à un autre élément de la paire de liaison, la paire de liaison pouvant générer un signal détectable.
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