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1. WO2020221768 - CHIMERIC PROTEINS AND METHODS TO SCREEN FOR COMPOUNDS AND LIGANDS BINDING TO GPCRS


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INTERNATIONAL SEARCH REPORT (ISR)
Part 1:  1  2  3  4  5  6          Part 2:  A  B  C  D  E 
International application No. Applicant's or agent's file reference
PCT/EP2020/061802 P6086124PCT
International filing date (day/month/year) (Earliest) Priority Date (day/month/year)
28 April 2020 29 April 2019
Applicant
CONFO THERAPEUTICS N.V.
FOR FURTHER ACTION: See Form PCT/ISA/220 as well as, where applicable, item 5 below.
This international search report has been prepared by this International Searching Authority and is transmitted to the applicant according to Article 18. A copy is being transmitted to the International Bureau.
It is also accompanied by a copy of each prior art document cited in this report.
1. Basis of the report
a. With regard to the language, the international search was carried out on the basis of:
the international application in the language in which it was filed.
a translation of the international application into                                          which is the language of a translation furnished for the purposes of international search (Rules 12.3(a) and 23.1(b)).
b.
This international search report has been established taking into account the rectification of an obvious mistake authorized by or notified to this Authority under Rule 91 (Rule 43.6bis(a)).
c.
1. With regard to any nucleotide and/or amino acid sequence disclosed in the international application, the international search was carried out on the basis of a sequence listing:
a. forming part of the international application as filed:
in the form of an Annex C/ST.25 text file.
on paper or in the form of an image file.
b. furnished together with the international application under PCT Rule 13ter.1(a) for the purposes of international search only in the form of an Annex C/ST.25 text file.
c. furnished subsequent to the international filing date for the purposes of international search only:
in the form of an Annex C/ST.25 text file (Rule 13ter.1(a)).
on paper or in the form of an image file (Rule 13ter.1(b) and Administrative Instructions, Section 713).
2.
In addition, in the case that more than one version or copy of a sequence listing has been filed or furnished, the required statements that the information in the subsequent or additional copies is identical to that forming part of the application as filed or does not go beyond the application as filed, as appropriate, were furnished.
3.
Additional comments:
2. Certain claims were found unsearchable
3. Unity of invention is lacking
4. Title of the invention
The text is approved as submitted by the applicant.
The text has been established by this Authority to read as follows:
5. Abstract
The text is approved as submitted by the applicant.
The text has been established, according to Rule 38.2, by this Authority as it appears in Box No. IV. The applicant may, within one month from the date of mailing of this international search report, submit comments to this Authority.
6. Drawings
a.
The figure of the drawings to be published with the abstract is Figure No. ____________
as suggested by the applicant.
as selected by this Authority, because the applicant failed to suggest a figure.
as selected by this Authority, because this figure better characterizes the invention.
b.
none of the figures is to be published with the abstract.

A. CLASSIFICATION OF SUBJECT MATTER

     G01N 33/566 (2006.01)i; C07K 14/705 (2006.01)i; C07K 14/72 (2006.01)i
According to International Patent Classification (IPC) or to both national classification and IPC

B. FIELDS SEARCHED

Minimum documentation searched (classification system followed by classification symbols):
     G01N; C07K
Documentation searched other than minimum documentation to the extent that such documents are included in the fields searched:
Electronic data base consulted during the international search (name of data base and, where practicable, search terms used):
EPO-Internal, BIOSIS, EMBASE, WPI Data

C. DOCUMENTS CONSIDERED TO BE RELEVANT

Category* Citation of document, with indication, where appropriate, of the relevant passages Relevant to claim No.
(1)
Y
Promega, "NanoBiT (TM) TECHNOLOGY Monitor the Dynamics of Protein:Protein Interactions in Living Cells", 01 January 2016 (2016-01-01), page 1-8,
Retrieved from the Internet:
URL:http://www.eastport.cz/dokumenty/brochure-nanobit-2016-engl_201705241124428.pdf
XP055698299
[retrieved on  2020-05-26]
12,13
p. 4
(2)
Y
CÉLINE LASCHET ET AL, "A dynamic and screening-compatible nanoluciferase-based complementation assay enables profiling of individual GPCR-G protein interactions", JOURNAL OF BIOLOGICAL CHEMISTRY,Vol. 294, No. 11, 28 December 2018 (2018-12-28), page 4079-4090,
XP055715055
12,13
Abstract; Fig. 1
(3)
Y
WO 2005101005 A1 (BAYER HEALTHCARE AG [DE]; GOLZ STEFAN [DE] ET AL.) 27 October 2005 (2005-10-27)
7,12-15
Abstract; example 6
(4)
X
MAURIZIO MORRI ET AL, "Optical functionalization of human Class A orphan G-protein-coupled receptors", NATURE COMMUNICATIONS,Vol. 9, No. 1, 16 May 2018 (2018-05-16),
XP055713498
1-6,8-11
Y
Abstract; Figures 1, 2, 4; Supplementary table 2
7,12-15
& MAURIZIO MORRI ET AL, "Supplementary Information.- Optical functionalization of human Class A orphan G-protein-coupled receptors",  NATURE COMMUNICATIONS,Vol. 9, No. 1, 16 December 2018 (2018-12-16),
XP055715605
Supplementary table 2
(5)
X
D. YIN, "Probing Receptor Structure/Function with Chimeric G-Protein-Coupled Receptors", MOLECULAR PHARMACOLOGY,Vol. 65, No. 6, 01 June 2004 (2004-06-01), page 1323-1332,
XP055094165
1-3,5,6,8-11
Y
Abstract; Fig 2, 3; p. 1325 "probing ligand binding domains of GPCR with chimeras"; on p. 1326 "probing downstream signaling with chimeric GPCRs" and on p. 1328 "probing ligands and downstream signaling for orphan GPCRs"
7,12-14
(6)
Y
WO 2012175643 A2 (VIB VZW [BE]; UNIV BRUXELLES [BE] ET AL.) 27 December 2012 (2012-12-27)
7
cited in the application
Abstract;
(7)
Y
WO 2015121092 A1 (VIB VZW [BE]; UNIV BRUXELLES [BE]; UNIV LELAND STANFORD JUNIOR [US]) 20 August 2015 (2015-08-20)
7
cited in the application
Abstract; examples 5, 6, 9
(8)
X
WO 2012174674 A1 (HAAG STREIT MEDTECH AG [CH]; VAN WYK MICHIEL [DE] ET AL.) 27 December 2012 (2012-12-27)
1-3,5,6,8
Y
Abstract; Fig 1; p. 25, l. 13-17.
7,12-15
(9)
X
WO 2008014382 A2 (UNIV CASE WESTERN RESERVE [US]; HERLITZE STEFAN [US] ET AL.) 31 January 2008 (2008-01-31)
1-3,5,6,8
Y
Abstract; Fig 1; col. 8, l. 46-55
7,12-15
(10)
X
XUNXIAN LIU ET AL, "Activation of a Frizzled-2/[beta] -adrenergic Receptor Chimera Promotes Wnt Signaling and Differentiation of Mouse F9 Teratocarcinoma Cells via G[alpha] o and G[alpha] t", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES,Vol. 96, No. 25, 07 December 1999 (1999-12-07), page 14383-14388,
XP055713708
1-3
Y
Abtract; Fig. 2
7,12-15
(11)
Y
WO 2014118297 A1 (VIB VZW [BE]; UNIV BRUXELLES [BE]) 07 August 2014 (2014-08-07)
7,12-15
cited in the application
Abstract; examples 1-23
*
Special categories of cited documents:
"A"
document defining the general state of the art which is not considered to be of particular relevance
"D"
document cited by the applicant in the international application
"E"
earlier application or patent but published on or after the international filing date
"L"
document which may throw doubts on priority claim(s) or which is cited to establish the publication date of another citation or other special reason (as specified)
"O"
document referring to an oral disclosure, use, exhibition or other means
"P"
document published prior to the international filing date but later than the priority date claimed
"T"
later document published after the international filing date or priority date and not in conflict with the application but cited to understand the principle or theory underlying the invention
"X"
document of particular relevance; the claimed invention cannot be considered novel or cannot be considered to involve an inventive step when the document is taken alone
"Y"
document of particular relevance; the claimed invention cannot be considered to involve an inventive step when the document is combined with one or more other such documents, such combination being obvious to a person skilled in the art
"&"
document member of the same patent family

D. INFORMATION ON PATENT FAMILY MEMBERS

Patent document cited in search report Publication date
(day/month/year)
Patent family member(s) Publication date
(day/month/year)
WO 2005101005 A1
27 October 2005
NONE
WO 2012175643 A2
27 December 2012
AU 2012273987 A1
BR 112013032451 A2
CA 2839834 A1
CN 104053667 A
CN 107857810 A
DK 2723764 T3
EP 2723764 A2
EP 3345919 A1
ES 2662372 T3
HR P20180443 T1
HU E036982 T2
JP 6164535 B2
JP 2014525735 A
JP 2017127306 A
NO 2723764 T3
PL 2723764 T3
PT 2723764 T
US 2014275487 A1
US 2017253644 A1
WO 2012175643 A2
30 January 2014
22 November 2016
27 December 2012
17 September 2014
30 March 2018
12 March 2018
30 April 2014
11 July 2018
06 April 2018
20 April 2018
28 August 2018
19 July 2017
02 October 2014
27 July 2017
26 May 2018
30 May 2018
09 March 2018
18 September 2014
07 September 2017
27 December 2012
WO 2015121092 A1
20 August 2015
AU 2015217846 A1
CA 2936728 A1
EP 3099707 A1
JP 6687525 B2
JP 2017506505 A
US 2017183404 A1
US 2019338024 A1
WO 2015121092 A1
28 July 2016
20 August 2015
07 December 2016
22 April 2020
09 March 2017
29 June 2017
07 November 2019
20 August 2015
WO 2012174674 A1
27 December 2012
AU 2012272505 A1
BR 112013033028 A2
CA 2840458 A1
CN 103814045 A
CN 107383184 A
DK 3029063 T3
EP 2723767 A1
EP 3029063 A1
ES 2766398 T3
HR P20200004 T1
HU E047074 T2
JP 6240067 B2
JP 2014524903 A
KR 20140039281 A
LT 3029063 T
PL 2723767 T3
PL 3029063 T3
PT 3029063 T
RU 2014101708 A
SI 3029063 T1
US 2014171376 A1
WO 2012174674 A1
ZA 201308824 B
16 January 2014
31 January 2017
27 December 2012
21 May 2014
24 November 2017
20 January 2020
30 April 2014
08 June 2016
12 June 2020
15 May 2020
28 April 2020
29 November 2017
25 September 2014
01 April 2014
10 February 2020
30 June 2016
18 May 2020
22 January 2020
27 July 2015
31 March 2020
19 June 2014
27 December 2012
25 February 2015
WO 2008014382 A2
31 January 2008
US 2010009444 A1
US 2016333069 A1
WO 2008014382 A2
14 January 2010
17 November 2016
31 January 2008
WO 2014118297 A1
07 August 2014
AU 2014211355 A1
CA 2899693 A1
CN 105102478 A
DK 2951201 T3
EP 2951201 A1
ES 2654675 T3
HR P20171777 T1
HU E035315 T2
JP 6443344 B2
JP 2016504919 A
NO 2951201 T3
PL 2951201 T3
PT 2951201 T
US 2015376261 A1
WO 2014118297 A1
06 August 2015
07 August 2014
25 November 2015
08 January 2018
09 December 2015
14 February 2018
29 December 2017
02 May 2018
26 December 2018
18 February 2016
17 March 2018
30 March 2018
09 January 2018
31 December 2015
07 August 2014
Name and mailing address of the ISA/:
European Patent Office
P.B. 5818, Patentlaan 2, 2280 HV Rijswijk,
Netherlands
Telephone No. (+31-70)340-2040
Facsimile No. (+31-70)340-3016
Date of the actual completion of the international search:
17 July 2020
Date of mailing of the international search report:
29 July 2020
Authorized officer:
López García, F
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