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1. WO2020221466 - BIOLOGICAL BINDING MOLECULES

Publication Number WO/2020/221466
Publication Date 05.11.2020
International Application No. PCT/EP2019/061308
International Filing Date 02.05.2019
IPC
A61P 35/02 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
02specific for leukemia
C07K 16/28 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18against material from animals or humans
28against receptors, cell surface antigens or cell surface determinants
C07K 16/30 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18against material from animals or humans
28against receptors, cell surface antigens or cell surface determinants
30from tumour cells
CPC
C07K 16/2803
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
18against material from animals or humans
28against receptors, cell surface antigens or cell surface determinants
2803against the immunoglobulin superfamily
C07K 16/3061
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
18against material from animals or humans
28against receptors, cell surface antigens or cell surface determinants
30from tumour cells
3061Blood cells
C07K 2317/24
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
2317Immunoglobulins specific features
20characterized by taxonomic origin
24containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
Applicants
  • AVA LIFESCIENCE GMBH [DE]/[DE]
Inventors
  • KLAPPROTH, Holger
  • KESSEMEIER, Marc A.
  • BIRSNER, Ulrich
Agents
  • CACACE, Sabrina
Priority Data
Publication Language German (DE)
Filing Language German (DE)
Designated States
Title
(DE) BIOLOGISCHE BINDEMOLEKÜLE
(EN) BIOLOGICAL BINDING MOLECULES
(FR) MOLÉCULES DE LIAISON BIOLOGIQUES
Abstract
(DE)
Die vorliegende Erfindung betrifft das Gebiet der Herstellung, Identifizierung und Selektion von biologischen Bindemolekülen wie Antikörpern oder Fragmenten derselben, sowie deren Verwendung im Rahmen der Diagnose und Therapie von Krebserkrankungen wie insbesondere malignen B-Zell Neoplasien. Die Bindemoleküle sind in der Lage, selektiv an B-Zell Rezeptoren zu binden, die eine leichte Kette gemäß SEQ ID NO. 18 aufweisen.
(EN)
The invention relates to the field of the preparation, identification and selection of biological binding molecules such as antibodies or fragments thereof, and also the use thereof in the context of therapy and prophylaxis of cancers, such as malignant B-cell neoplasia in particular. The binding molecules are capable of selectively binding to B-cell receptors that have a light chain according to SEQ ID NO. 18.
(FR)
La présente invention concerne le domaine de la production, de l'identification et de la sélection de molécules de liaison biologiques, telles que des anticorps ou des fragments de ces derniers, ainsi que leur utilisation dans le cadre du diagnostic et du traitement de maladies cancéreuses, telles que les néoplasies malignes des lymphocytes B. Les molécules de liaison biologiques sont aptes à se lier sélectivement aux récepteurs de lymphocytes B qui présentent une chaîne légère selon SEQ ID NO. 18.
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