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1. WO2020221376 - COMPOUND FOR PREVENTING AND/OR TREATING CANCER, AND PREPARATION METHOD THEREFOR AND APPLICATION THEREOF

Publication Number WO/2020/221376
Publication Date 05.11.2020
International Application No. PCT/CN2020/098472
International Filing Date 28.06.2020
IPC
C07D 239/96 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
239Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
70condensed with carbocyclic rings or ring systems
72Quinazolines; Hydrogenated quinazolines
95with hetero atoms directly attached in positions 2 and 4
96Two oxygen atoms
C07D 239/80 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
239Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
70condensed with carbocyclic rings or ring systems
72Quinazolines; Hydrogenated quinazolines
78with hetero atoms directly attached in position 2
80Oxygen atoms
A61P 35/00 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
CPC
A61K 31/166
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
16Amides, e.g. hydroxamic acids
165having aromatic rings, e.g. colchicine, atenolol, progabide
166having the carbon of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
A61K 31/517
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
495having six-membered rings with two ; or more; nitrogen atoms as the only ring heteroatoms, e.g. piperazine ; or tetrazines
505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
517ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
A61P 35/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
A61P 35/02
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
02specific for leukemia
C07C 237/30
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
237Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
28having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
30having the nitrogen atom of the carboxamide group bound to hydrogen atoms or to acyclic carbon atoms
C07D 239/80
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
239Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
70condensed with carbocyclic rings or ring systems
72Quinazolines; Hydrogenated quinazolines
78with hetero atoms directly attached in position 2
80Oxygen atoms
Applicants
  • 北京嘉林药业股份有限公司 BEIJING JIALIN PHARMACEUTICAL CO. LTD. [CN]/[CN]
Inventors
  • 何伟 HE, Wei
Agents
  • 北京高沃律师事务所 BEIJING GAOWO LAW FIRM
Priority Data
201910357130.329.04.2019CN
Publication Language Chinese (zh)
Filing Language Chinese (ZH)
Designated States
Title
(EN) COMPOUND FOR PREVENTING AND/OR TREATING CANCER, AND PREPARATION METHOD THEREFOR AND APPLICATION THEREOF
(FR) COMPOSÉ POUR LA PRÉVENTION ET/OU LE TRAITEMENT DU CANCER, SON PROCÉDÉ DE PRÉPARATION ET SON APPLICATION
(ZH) 一种预防和/或治疗癌症的化合物及其制备方法和应用
Abstract
(EN) Provided is a compound as shown in formula (I), and pharmaceutically acceptable salts, stereoisomers, ethers, esters, prodrugs and solvates thereof, the compound being used for preventing and/or treating cancer.
(FR) L'invention concerne un composé tel que représenté dans la formule (I), et des sels, des stéréoisomères, des éthers, des esters, des promédicaments et des solvates pharmaceutiquement acceptables de celui-ci, le composé étant utilisé pour prévenir et/ou traiter le cancer.
(ZH) 本发明提供了式(I)的化合物,及其药学上可接受的盐、立体异构体、醚、酯、前药和溶剂化物,所述的化合物能够用于预防和/或治疗癌症,
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