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1. WO2020221334 - PIM1 INHIBITORS FOR USE IN TREATMENT OF VIRAL INFECTION AND PHARMACEUTICAL COMPOSITIONS THEREOF

Publication Number WO/2020/221334
Publication Date 05.11.2020
International Application No. PCT/CN2020/088009
International Filing Date 30.04.2020
IPC
A61K 48/00 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
48Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
A61K 45/00 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
45Medicinal preparations containing active ingredients not provided for in groups A61K31/-A61K41/132
A61P 31/14 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
12Antivirals
14for RNA viruses
CPC
A61K 31/454
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
435having six-membered rings with one nitrogen as the only ring hetero atom
44Non condensed pyridines; Hydrogenated derivatives thereof
445Non condensed piperidines, e.g. piperocaine
4523containing further heterocyclic ring systems
454containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
A61K 31/5025
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
495having six-membered rings with two ; or more; nitrogen atoms as the only ring heteroatoms, e.g. piperazine ; or tetrazines
50Pyridazines; Hydrogenated pyridazines
5025ortho- or peri-condensed with heterocyclic ring systems
A61K 31/545
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
54having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
542ortho- or peri-condensed with heterocyclic ring systems
545Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula: , e.g. cephalosporins, ; cefaclor, or cephalexine
A61K 31/551
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
55having seven-membered rings, e.g. azelastine, pentylenetetrazole
551having two nitrogen atoms, e.g. dilazep
A61K 31/7088
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
70Carbohydrates; Sugars; Derivatives thereof
7088Compounds having three or more nucleosides or nucleotides
A61P 31/14
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
12Antivirals
14for RNA viruses
Applicants
  • CITY UNIVERSITY OF HONG KONG [CN]/[CN]
Inventors
  • HE, Ming-Liang
  • CHEN, Ying
  • ZHOU, Fanghang
  • WAN, Qianya
Agents
  • RUNPING & PARTNERS
Priority Data
62/840,81930.04.2019US
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) PIM1 INHIBITORS FOR USE IN TREATMENT OF VIRAL INFECTION AND PHARMACEUTICAL COMPOSITIONS THEREOF
(FR) INHIBITEURS DE PIM1 DESTINÉS À ÊTRE UTILISÉS DANS LE TRAITEMENT D'UNE INFECTION VIRALE, ET COMPOSITIONS PHARMACEUTIQUES DE CEUX-CI
Abstract
(EN) A Pim-1 proto-oncogene, serine/threonine kinase (PIM1) inhibitor for use in the treatment of a viral infection or use of said PIM1 inhibitor in the preparation of a medicament for said treatment. A method of treating a human afflicted with a viral infection. The method comprises administering, to the human, an effective antiviral amount of a PIM1 inhibitor. A pharmaceutical composition for treating a viral infection comprising a PIM1 inhibitor and a pharmaceutically acceptable excipient.
(FR) L'invention concerne un inhibiteur de la sérine/thréonine kinase codée par le proto-oncogène Pim-1 (kinase PIM1), destiné à être utilisé dans le traitement d'une infection virale, ou l'utilisation dudit inhibiteur de la PIM1 dans la préparation d'un médicament pour ledit traitement. L'invention concerne également une méthode de traitement d'un être humain atteint d'une infection virale. La méthode comprend l'administration à l'humain d'une quantité antivirale efficace d'un inhibiteur de la PIM1. L'invention concerne également une composition pharmaceutique pour traiter une infection virale, comprenant un inhibiteur de la PIM1 et un excipient pharmaceutiquement acceptable.
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