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1. WO2020221294 - BRIDGE RING-3,4-DIHYDRO-PYRIDO[1,2-A]PYRAZINE-1,8-DIONE COMPOUND AND PHARMACEUTICAL USE THEREOF

Publication Number WO/2020/221294
Publication Date 05.11.2020
International Application No. PCT/CN2020/087774
International Filing Date 29.04.2020
IPC
C07D 471/00 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
471Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/-C07D463/251
C07D 487/00 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
487Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/-C07D477/183
A61K 31/4985 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
495having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
4985Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
A61K 31/55 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
55having seven-membered rings, e.g. azelastine, pentylenetetrazole
A61P 31/18 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
12Antivirals
14for RNA viruses
18for HIV
Applicants
  • 上海拓界生物医药科技有限公司 TUOJIE BIOTECH (SHANGHAI) CO., LTD. [CN]/[CN]
Inventors
  • 祝伟 ZHU, Wei
  • 连韶 LIAN, Shao
  • 刘彪 LIU, Biao
  • 王元昊 WANG, Yuanhao
  • 余健 YU, Jian
  • 邹昊 ZOU, Hao
  • 李正涛 LI, Zhengtao
Agents
  • 北京戈程知识产权代理有限公司 GE CHENG & CO., LTD
Priority Data
201910359186.230.04.2019CN
201910862609.212.09.2019CN
Publication Language Chinese (ZH)
Filing Language Chinese (ZH)
Designated States
Title
(EN) BRIDGE RING-3,4-DIHYDRO-PYRIDO[1,2-A]PYRAZINE-1,8-DIONE COMPOUND AND PHARMACEUTICAL USE THEREOF
(FR) COMPOSÉ DE 3,4-DIHYDRO-PYRIDO[1,2-A]PYRAZINE-1,8-DIONE CYCLIQUE EN PONT ET SON UTILISATION PHARMACEUTIQUE
(ZH) 桥环-3,4-二氢-吡啶并[1,2-a]吡嗪-1,8-二酮化合物及其药物用途
Abstract
(EN)
A bridge ring-3,4-dihydro-pyrido[1,2-a]pyrazine-1,8-dione compound and a pharmaceutical use thereof. Specifically provided are the compound shown in formula I or a pharmaceutically acceptable salt or stereoisomer, rotamer, or tautomer thereof, wherein R1-R8 are as defined in the present text. The compound shown in formula I can be used for the treatment of human immunodeficiency virus (HIV) infection.
(FR)
L'invention concerne un composé de 3,4-dihydro-pyrido [1,2-a]pyrazine-1,8-dione cyclique en pont et son utilisation pharmaceutique. L'invention concerne spécifiquement le composé représenté par la formule I ou un sel ou stéréoisomère, rotamère, ou tautomère pharmaceutiquement acceptable de celui-ci, R1-R8 étant tels que définis dans lla description. Le composé représenté dans la formule I peut être utilisé pour le traitement d'une infection par le virus de l'immunodéficience humaine (VIH).
(ZH)
一种涉及桥环-3,4-二氢-吡啶并[1,2-a]吡嗪-1,8-二酮化合物及其药物用途。具体而言,提供一种式I所示化合物或其可药用的盐或其立体异构体、旋转异构体或互变异构体,其中R 1-R 8如本文定义的。所述式I所示化合物可用于治疗人类免疫缺陷病毒(HIV)感染。
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