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1. WO2020221280 - DIHYDROPYRIMIDINE COMPOUND AND APPLICATION THEREOF AS DRUG

Publication Number WO/2020/221280
Publication Date 05.11.2020
International Application No. PCT/CN2020/087700
International Filing Date 29.04.2020
IPC
C07D 487/04 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
487Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/-C07D477/183
02in which the condensed system contains two hetero rings
04Ortho-condensed systems
A61P 31/20 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
12Antivirals
20for DNA viruses
A61P 35/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
A61P 1/16 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1Drugs for disorders of the alimentary tract or the digestive system
16for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
A61K 31/506 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
495having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
506not condensed and containing further heterocyclic rings
A61K 45/06 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
45Medicinal preparations containing active ingredients not provided for in groups A61K31/-A61K41/132
06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
Applicants
  • 广东东阳光药业有限公司 SUNSHINE LAKE PHARMA CO., LTD. [CN]/[CN]
Inventors
  • 任青云 REN, Qingyun
  • 张英俊 ZHANG, Yingjun
  • 刘辛昌 LIU, Xinchang
  • S•戈尔德曼 GOLDMANN, Siegfried
  • 颜光华 YAN, Guanghua
  • 王猛 WANG, Meng
  • 雷斗兴 LEI, Douxing
  • 李凤 LI, Feng
Priority Data
201910360129.630.04.2019CN
Publication Language Chinese (ZH)
Filing Language Chinese (ZH)
Designated States
Title
(EN) DIHYDROPYRIMIDINE COMPOUND AND APPLICATION THEREOF AS DRUG
(FR) COMPOSÉ DIHYDROPYRIMIDINE ET SON UTILISATION EN TANT QUE MÉDICAMENT
(ZH) 二氢嘧啶类化合物及其在药物中的应用
Abstract
(EN)
A dihydropyrimidine compound and application thereof as a drug, in particular, application as a drug for treating and preventing hepatitis B. Specifically, the present invention relates to a compound represented by general formula (I) or (Ia) or a stereoisomer, a tautomer, an oxynitride, a solvate, a metabolite, a pharmaceutically acceptable salt or a prodrug thereof, wherein variables are as defined in the description. The present invention also relates to use of the compound represented by general formula (I) or (Ia) or the stereoisomer, the tautomer, the oxynitride, the solvate, the metabolite, or the pharmaceutically acceptable salt thereof as a drug, in particular use as a drug for treating and preventing hepatitis B.
(FR)
La présente invention concerne un composé dihydropyrimidine et son utilisation en tant que médicament, en particulier en tant que médicament pour le traitement et la prévention de l'hépatite B. Plus particulièrement, la présente invention concerne un composé représenté par la formule générale (I) ou (Ia) ou un stéréoisomère, un tautomère, un oxynitrure, un solvate, un métabolite, un sel pharmaceutiquement acceptable ou un promédicament de celui-ci, les variables étant tels que définis dans la description. La présente invention concerne également l'utilisation du composé représenté par la formule générale (I) ou (Ia) ou un stéréoisomère, un tautomère, un oxynitrure, un solvate, un métabolite, ou un sel pharmaceutiquement acceptable de celui-ci en tant que médicament, en particulier en tant que médicament pour le traitement et la prévention de l'hépatite B.
(ZH)
一种二氢嘧啶类化合物及其在药物中的应用,尤其是作为治疗和预防乙型肝炎的药物的应用。具体地说,涉及通式(I)或式(Ia)所示的化合物或其立体异构体、互变异构体、氮氧化物、溶剂化物、代谢产物、药学上可接受的盐或它的前药,其中各变量如说明书所定义。还涉及通式(I)或式(Ia)所示的化合物或或其立体异构体、互变异构体、氮氧化物、溶剂化物、代谢产物或药学上可接受的盐作为药物的用途,尤其是作为治疗和预防乙型肝炎的药物的用途。
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