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1. WO2020221239 - OXAAZAQUINAZOLINE-7(8H)-KETONE COMPOUND, PREPARATION METHOD THERFOR AND PHARMACEUTICAL APPLICATION THEREOF

Publication Number WO/2020/221239
Publication Date 05.11.2020
International Application No. PCT/CN2020/087428
International Filing Date 28.04.2020
IPC
C07D 498/14 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
498Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
12in which the condensed system contains three hetero rings
14Ortho-condensed systems
A61K 31/519 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
495having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
519ortho- or peri-condensed with heterocyclic rings
A61P 35/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
Applicants
  • 劲方医药科技(上海)有限公司 GENFLEET THERAPEUTICS (SHANGHAI) INC. [CN]/[CN]
  • 浙江劲方药业有限公司 ZHEJIANG GENFLEET THERAPEUTICS CO., LTD. [CN]/[CN]
Inventors
  • 周福生 ZHOU, Fusheng
  • 蔡礼健 CAI, Lijian
  • 蒋涛 JIANG, Tao
  • 赵吉辰 ZHAO, Jichen
  • 刘颖涛 LIU, Yingtao
  • 赵金柱 ZHAO, Jinzhu
  • 张磊涛 ZHANG, Leitao
  • 刘柱博 LIU, Zhubo
  • 彭灵 PENG, Ling
  • 何宛 HE, Wan
  • 杨华彬 YANG, Huabin
  • 张涛 ZHANG, Tao
  • 丁茜 DING, Qian
  • 郑彪 ZHENG, Biao
  • 吕强 LV, Qiang
  • 兰炯 LAN, Jiong
Agents
  • 上海上谷知识产权代理有限公司 SHANGHAI GOOIP CO., LTD.
Priority Data
201910349813.428.04.2019CN
Publication Language Chinese (ZH)
Filing Language Chinese (ZH)
Designated States
Title
(EN) OXAAZAQUINAZOLINE-7(8H)-KETONE COMPOUND, PREPARATION METHOD THERFOR AND PHARMACEUTICAL APPLICATION THEREOF
(FR) COMPOSÉ OXAAZAQUINAZOLINE-7(8H)-CÉTONE, SON PROCÉDÉ DE PRÉPARATION ET SON APPLICATION PHARMACEUTIQUE
(ZH) 氧杂氮杂喹唑啉-7(8H)-酮类化合物,其制法与医药上的用途
Abstract
(EN)
Disclosed are an oxazaazaquinazolin-7(8H)-ketone compound with a selective inhibition effect on KRAS gene mutation and pharmaceutically acceptable salts thereof, stereoisomers, solvent compounds or prodrugs (as shown in formula I or formula II, see the details of the definition to each group in the formulas in the specification), as well as the pharmaceutical composition containing the compound, and the application thereof in preparation of cancer medicine.
(FR)
L'invention concerne un composé oxazaazaquinazolin-7(8H)-cétone ayant un effet d'inhibition sélective sur la mutation du gène KRAS et des sels pharmaceutiquement acceptables de celui-ci, des stéréoisomères, des composés solvants ou des promédicaments (tels que représentés dans la formule I ou la formule II, voir les détails de la définition relative à chaque groupe dans les formules de la description), ainsi que la composition pharmaceutique contenant le composé, et son application dans la préparation d'un médicament contre le cancer. (I)
(ZH)
一种对KRAS基因突变具有选择抑制作用的氧杂氮杂喹唑啉-7(8H)-酮类化合物及其药学上可接受的盐、立体异构体、溶剂化合物或前药,如式I或式II所示,式中各基团的定义详见说明书包含该化合物的药物组合物,及其在制备癌症药物中的应用。
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