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1. WO2020221006 - BET INHIBITOR, AND PREPARATION METHOD AND USE THEREOF

Publication Number WO/2020/221006
Publication Date 05.11.2020
International Application No. PCT/CN2020/084797
International Filing Date 14.04.2020
IPC
C07D 471/04 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
471Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/-C07D463/251
02in which the condensed system contains two hetero rings
04Ortho-condensed systems
C07D 487/04 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
487Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/-C07D477/183
02in which the condensed system contains two hetero rings
04Ortho-condensed systems
C07D 519/00 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
519Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/ or C07D455/257
C07D 413/04 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
413Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
02containing two hetero rings
04directly linked by a ring-member-to-ring- member bond
C07D 498/04 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
498Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
02in which the condensed system contains two hetero rings
04Ortho-condensed systems
A61K 31/538 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
535having six-membered rings with at least one nitrogen and at least one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
53751,4-Oxazines, e.g. morpholine
538ortho- or peri-condensed with carbocyclic ring systems
CPC
A61P 25/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
A61P 29/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
29Non-central analgesic, antipyretic or anti-inflammatory agents, e.g antirheumatic agents; Non-steroidal anti-inflammatory drugs (NSAIDs)
A61P 31/04
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
04Antibacterial agents
A61P 31/12
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
12Antivirals
A61P 35/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
A61P 35/02
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
02specific for leukemia
Applicants
  • 上海勋和医药科技有限公司 SHANGHAI XUNHE PHARMACEUTICAL TECHNOLOGY CO.LTD. [CN]/[CN]
Inventors
  • 郑永勇 ZHENG, Yongyong
  • 魏农农 WEI, Nongnong
  • 金华 JIN, Hua
  • 周峰 ZHOU, Feng
  • 黄美花 HUANG, Meihua
Agents
  • 常州市权航专利代理有限公司 CHANGZHOU RIGHT NAVIGATION PATENT AGENCY CO, LTD.
Priority Data
201910360142.130.04.2019CN
Publication Language Chinese (ZH)
Filing Language Chinese (ZH)
Designated States
Title
(EN) BET INHIBITOR, AND PREPARATION METHOD AND USE THEREOF
(FR) INHIBITEUR DE BET, SON PROCÉDÉ DE PRÉPARATION ET SON UTILISATION
(ZH) 一种BET蛋白抑制剂、其制备方法及用途
Abstract
(EN)
The present invention relates to the technical field of biomedicine, and specifically relates to a BET inhibitor, and a preparation method and use thereof. The present invention improves on the structure of prior art BET inhibitors to obtain a class of BET inhibitors having a new structure, better BET inhibition activity and good pharmacokinetics, and has prospects for development as a new highly efficient and low-toxicity BET inhibitor.
(FR)
La présente invention concerne le domaine technique de la biomédecine, et concerne spécifiquement un inhibiteur de BET, son procédé de préparation et son utilisation. La présente invention améliore la structure d'inhibiteurs de BET de la technique antérieure pour obtenir une classe d'inhibiteurs de BET ayant une nouvelle structure, une meilleure activité d'inhibition de BET et une bonne pharmacocinétique, et a des perspectives de développement en tant qu'inhibiteur de BET de faible toxicité et très efficace.
(ZH)
本发明属于生物医药技术领域,具体涉及一种BET蛋白抑制剂、其制备方法及用途。与现有技术相比,本发明在现有BET蛋白抑制剂基础上进一步进行结构改进,得到一类新结构的BET蛋白抑制剂,其具有较好的BET蛋白抑制活性及良好的药代动力学性质,有望开发为新一代高效低毒的BET蛋白抑制剂。
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