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1. WO2020220994 - MICRORNA MARKER COMBINATION FOR DIAGNOSING GASTRIC CANCER AND DIAGNOSTIC KIT

Publication Number WO/2020/220994
Publication Date 05.11.2020
International Application No. PCT/CN2020/084687
International Filing Date 14.04.2020
IPC
C12Q 1/68 2018.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
68involving nucleic acids
CPC
C12Q 1/6886
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms
68involving nucleic acids
6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
6883for diseases caused by alterations of genetic material
6886for cancer
C12Q 2600/158
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS
2600Oligonucleotides characterized by their use
158Expression markers
C12Q 2600/178
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS
2600Oligonucleotides characterized by their use
178miRNA, siRNA or ncRNA
Applicants
  • 觅瑞实验室私人有限公司 MIRXES LAB PTE.LTD. [SG]/[CN]
Inventors
  • 邹瑞阳 ZOU, Ruiyang
Agents
  • 北京集佳知识产权代理有限公司 UNITALEN ATTORNEYS AT LAW
Priority Data
201910392316.230.04.2019CN
Publication Language Chinese (ZH)
Filing Language Chinese (ZH)
Designated States
Title
(EN) MICRORNA MARKER COMBINATION FOR DIAGNOSING GASTRIC CANCER AND DIAGNOSTIC KIT
(FR) COMBINAISON DE MARQUEUR DE MICROARN POUR DIAGNOSTIQUER UN CANCER GASTRIQUE ET KIT DE DIAGNOSTIC
(ZH) 一种检测胃癌的miRNA标志物组合及试剂盒
Abstract
(EN)
The present invention relates to the field of molecular biology. Disclosed are a microRNA marker combination for diagnosing gastric cancer and a diagnostic kit. The microRNA marker combination for diagnosing gastric cancer includes at least four markers selected from: hsa-miR-29c-3p, hsa-miR-424-5p,hsa-miR-103a-3p, hsa-miR-93-5p, hsa-miR-181a-5p, hsa-miR-21-5p, hsa-miR-140-5p, hsa-miR-30e-5p, hsa-miR-142-5p, hsa-miR-126-3p, hsa-miR-183-5p and hsa-miR-340-5p. The marker combination for diagnosing gastric cancer can be used to distinguish blood serum of a patient with gastric cancer from that of a healthy person. The diagnostic kit of the present invention can diagnose gastric cancers easily, effectively and non-invasively.
(FR)
La présente invention concerne le domaine de la biologie moléculaire. L'invention concerne une combinaison de marqueurs de microARN pour diagnostiquer un cancer gastrique et une trousse de diagnostic. La combinaison de marqueurs de microARN pour diagnostiquer un cancer gastrique comprend au moins quatre marqueurs choisis parmi : hsa-miR-29c-3p, hsa-miR-424-5p, hsa-miR-103a-3p, hsa-miR-93-5p, hsa-miR-181a-5p, hsa-miR-21-5p, hsa-miR-140-5p, hsa-miR-30 e-5p, hsa-miR-142-5p, hsa-miR-126-3p, hsa-miR-183-5p et hsa-miR-340-5p. La combinaison de marqueurs pour diagnostiquer un cancer gastrique peut être utilisée pour distinguer le sérum sanguin d'un patient atteint d'un cancer gastrique à partir de celui d'une personne en bonne santé. Le kit de diagnostic de la présente invention peut diagnostiquer facilement, de manière efficace et non invasive des cancers gastriques.
(ZH)
本发明属于分子生物学领域,公开了一种检测胃癌的miRNA标志物组合及试剂盒所述检测胃癌的miRNA标志物组合选自hsa-miR-29c-3p、hsa-miR-424-5p、hsa-miR-103a-3p、hsa-miR-93-5p、hsa-miR-181a-5p、hsa-miR-21-5p、hsa-miR-140-5p、hsa-miR-30e-5p、hsa-miR-142-5p、hsa-miR-126-3p、hsa-miR-183-5p或hsa-miR-340-5p中至少4个。采用所述检测胃癌的标志物组合可以区分胃癌患者的血清和健康人的血清。本发明所述试剂盒可以简单有效且无创的对胃癌进行检测。
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