Processing

Please wait...

Settings

Settings

Goto Application

1. WO2020220562 - BENZOFURAN-6-FORMAMIDE DERIVATIVE, PREPARATION METHOD THEREFOR, AND PHARMACEUTICAL APPLICATION THEREOF

Publication Number WO/2020/220562
Publication Date 05.11.2020
International Application No. PCT/CN2019/105994
International Filing Date 16.09.2019
IPC
C07D 307/80 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
307Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
77ortho- or peri-condensed with carbocyclic rings or ring systems
78Benzo furans; Hydrogenated benzo furans
79with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
80Radicals substituted by oxygen atoms
C07D 405/12 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
405Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
02containing two hetero rings
12linked by a chain containing hetero atoms as chain links
C07D 405/14 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
405Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
14containing three or more hetero rings
A61K 31/343 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
335having oxygen as the only ring hetero atom, e.g. fungichromin
34having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
343condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
A61K 31/443 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
435having six-membered rings with one nitrogen as the only ring hetero atom
44Non-condensed pyridines; Hydrogenated derivatives thereof
4427containing further heterocyclic ring systems
443containing a five-membered ring with oxygen as a ring hetero atom
A61P 35/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
Applicants
  • 上海和誉生物医药科技有限公司 ABBISKO THERAPEUTICS CO., LTD. [CN]/[CN]
Inventors
  • 寻国良 XUN, Guoliang
  • 赵保卫 ZHAO, Baowei
  • 喻红平 YU, Hongping
  • 陈椎 CHEN, Zhui
  • 徐耀昌 XU, Yaochang
Agents
  • 上海一平知识产权代理有限公司 XU & PARTNERS, LLC.
Priority Data
201910356174.429.04.2019CN
Publication Language Chinese (ZH)
Filing Language Chinese (ZH)
Designated States
Title
(EN) BENZOFURAN-6-FORMAMIDE DERIVATIVE, PREPARATION METHOD THEREFOR, AND PHARMACEUTICAL APPLICATION THEREOF
(FR) DÉRIVÉ DE BENZOFURAN-6-FORMAMIDE, SON PROCÉDÉ DE PRÉPARATION ET SON APPLICATION PHARMACEUTIQUE
(ZH) 苯并呋喃-6-甲酰胺衍生物、其制备方法和药学上的应用
Abstract
(EN)
A benzofuran-6-formamide derivative having a structure represented by formula (I), a preparation method therefor, and a pharmaceutical application thereof. The definition of each substituent is as described in the description and the claims. A series of compounds in the present invention can be widely used in preparation of drugs for treating one or more tumors, cancers, metabolic diseases, autoimmune diseases or disorders, and are expected to be developed into new-generation RORγt agonist drugs.
(FR)
L'invention concerne un dérivé de benzofuran-6-formamide ayant une structure représentée par la formule (I), son procédé de préparation, et une application pharmaceutique de celui-ci. La définition de chaque substituant est telle que décrite dans la description et les revendications. Une série de composés de la présente invention peuvent être largement utilisés dans la préparation de médicaments destinés à traiter une ou plusieurs maladies parmi les tumeurs, les cancers, les maladies métaboliques, les maladies ou troubles auto-immuns, et sont supposés être développés en médicaments agonistes de RORγt de nouvelle génération.
(ZH)
一种具有式(I)结构的苯并呋喃-6-甲酰胺衍生物、其制备方法和药学上的应用,各取代基的定义如说明书和权利要求书所述。本发明系列化合物可广泛应用于制备治疗一种或多种肿瘤、癌症、代谢性疾病、自身免疫性疾病或紊乱的药物,有望开发成新一代RORγt激动剂药物。
Latest bibliographic data on file with the International Bureau