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1. WO2020219358 - CATALYTICALLY INACTIVE BOTULINUM NEUROTOXIN-LIKE TOXINS AND USES THEREOF

Publication Number WO/2020/219358
Publication Date 29.10.2020
International Application No. PCT/US2020/028742
International Filing Date 17.04.2020
IPC
A61K 39/08 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
02Bacterial antigens
08Clostridium, e.g. Clostridium tetani
CPC
A61K 38/164
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
164from bacteria
A61K 39/08
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
02Bacterial antigens
08Clostridium, e.g. Clostridium tetani
Applicants
  • CHILDREN'S MEDICAL CENTER CORPORATION [US]/[US]
Inventors
  • DONG, Min
  • MIYASHITA, Shin-Ichiro
Agents
  • GE, Zhiyun
Priority Data
62/835,15117.04.2019US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) CATALYTICALLY INACTIVE BOTULINUM NEUROTOXIN-LIKE TOXINS AND USES THEREOF
(FR) TOXINES DE TYPE NEUROTOXINE BOTULIQUE CATALYTIQUEMENT INACTIVES ET LEURS UTILISATIONS
Abstract
(EN)
Provided herein, in aspects, are catalytically inactive BoNT-like toxins from Clostridium botulinum, serotype X (BoNT/X), from Enterococcus faecium (BoNT/En) or from Paraclostridium bifermentans (BoNT/PMP1) and their use as delivery vehicles to deliver an agent (e.g., a therapeutic agent or a diagnostic agent) to a cell. Methods of treating a disease (e.g., botulism) are also provided.
(FR)
Dans certains aspects, des toxines de type BoNT catalytiquement inactives de Clostridium botulinum, sérotype X (BoNT/X), issues d'Enterococcus Faecium (BoNT/En)) ou de Paraclostridium bifermentans (BoNT/PMP1) et leur utilisation en tant que véhicules d'administration pour administrer un agent (par exemple, un agent thérapeutique ou un agent de diagnostic) à une cellule. L'invention concerne également des méthodes de traitement d'une maladie (par ex. le botulisme).
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