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1. WO2020210831 - INHIBITORS OF CD40-CD154 BINDING

Publication Number WO/2020/210831
Publication Date 15.10.2020
International Application No. PCT/US2020/028002
International Filing Date 13.04.2020
IPC
A61K 31/18 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
16Amides, e.g. hydroxamic acids
18Sulfonamides
A61K 31/44 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
435having six-membered rings with one nitrogen as the only ring hetero atom
44Non-condensed pyridines; Hydrogenated derivatives thereof
A61K 31/4406 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
435having six-membered rings with one nitrogen as the only ring hetero atom
44Non-condensed pyridines; Hydrogenated derivatives thereof
4406only substituted in position 3, e.g. zimeldine
C07C 13/20 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
13Cyclic hydrocarbons containing rings other than, or in addition to, six-membered aromatic rings
02Monocyclic hydrocarbons or acyclic hydrocarbon derivatives thereof
16with a six-membered ring
20with a cyclohexene ring
C07D 213/04 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
213Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
02having three double bonds between ring members or between ring members and non-ring members
04having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
Applicants
  • TONIX PHARMACEUTICALS HOLDING CORP [US]/[US]
Inventors
  • RIDEOUT, Darryl
  • LEDERMAN, Seth
Agents
  • PRINCE, Robert
Priority Data
62/833,47312.04.2019US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) INHIBITORS OF CD40-CD154 BINDING
(FR) INHIBITEURS DE LIAISON CD40-CD154
Abstract
(EN)
Disclosed herein are compounds including pharmaceutically acceptable salts, esters, prodrugs, hydrates and tautomers thereof which modulate the interactions of CD-40-CD40L. The compounds are useful for treating, ameliorating or preventing an autoimmune disease, inflammatory disease, or other immune-related disease in a patient in need of treatment.
(FR)
L'invention concerne des composés comprenant des sels pharmaceutiquement acceptables, des esters, des promédicaments, des hydrates et des tautomères de ceux-ci qui modulent les interactions de CD-40-CD40L. Les composés sont utiles pour le traitement, l'atténuation ou la prévention d'une maladie auto-immune, d'une maladie inflammatoire ou d'une autre maladie liée à l'immunité chez un patient ayant besoin d'un tel traitement.
Latest bibliographic data on file with the International Bureau