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1. WO2020210451 - DEGRADERS OF FIBROBLAST GROWTH FACTOR RECEPTOR 2 (FGFR2)

Publication Number WO/2020/210451
Publication Date 15.10.2020
International Application No. PCT/US2020/027412
International Filing Date 09.04.2020
IPC
A61K 31/4045 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
40having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
403condensed with carbocyclic rings, e.g. carbazole
404Indoles, e.g. pindolol
4045Indole-alkylamines; Amides thereof, e.g. serotonin, melatonin
A61K 39/395 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
C07K 16/28 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18against material from animals or humans
28against receptors, cell surface antigens or cell surface determinants
Applicants
  • DANA-FARBER CANCER INSTITUTE, INC. [US]/[US]
Inventors
  • GRAY, Nathanael
  • ZHANG, Tinghu
  • DU, Guangyan
  • HENNING, Nathaniel
  • JIANG, Jie
Agents
  • CLARKE, Daniel W.
  • PYSHER, Paul
  • CHACLAS, George N.
  • COHEN, Jerry
  • EMMONS, Richard B.
  • COWLES, Christopher R.
  • GOLDMAN, Gabriel
  • JOBSE, Bruce D.
  • MARAIA, Joseph M.
  • MCGRATH, Daniel
  • MILLS, Steven
  • MOORE, Ronda P.
  • QUINN, Joseph P.
  • SCHEPPER, Marlo M.
  • SERIO, John C.
  • SORKIN, Paul D.
  • SUSAN, Janine M.
  • FOLEY, Shawn
  • SCHULTZ, Christopher S.
  • KARIMI, Pegah
Priority Data
62/831,95210.04.2019US
62/884,42208.08.2019US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) DEGRADERS OF FIBROBLAST GROWTH FACTOR RECEPTOR 2 (FGFR2)
(FR) AGENTS DE DÉGRADATION DU RÉCEPTEUR 2 DU FACTEUR DE CROISSANCE DES FIBROBLASTES (FGFR2)
Abstract
(EN)
The present invention relates to bispecific compounds, compositions, and methods for treating diseases or conditions characterized or mediated by aberrant fibroblast growth factor receptor 2 (FGFR2) activity.
(FR)
La présente invention concerne des composés bispécifiques, des compositions et des méthodes de traitement de maladies ou d'affections caractérisées ou médiées par l'activité aberrante du récepteur 2 du facteur de croissance des fibroblastes (FGFR2).
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