Processing

Please wait...

Settings

Settings

Goto Application

1. WO2020209277 - NOVEL COMPOUND HAVING PD-L1 EXPRESSION-SUPPRESSING ACTION

Publication Number WO/2020/209277
Publication Date 15.10.2020
International Application No. PCT/JP2020/015771
International Filing Date 08.04.2020
IPC
A61K 39/39 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
39characterised by the immunostimulating additives, e.g. chemical adjuvants
A61P 31/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
A61P 31/06 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
04Antibacterial agents
06for tuberculosis
A61P 31/14 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
12Antivirals
14for RNA viruses
A61P 31/18 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
12Antivirals
14for RNA viruses
18for HIV
A61P 31/20 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
12Antivirals
20for DNA viruses
Applicants
  • 国立大学法人東北大学 TOHOKU UNIVERSITY [JP]/[JP]
  • 学校法人順正学園 JUNSEI EDUCATIONAL INSTITUTION [JP]/[JP]
  • 扶桑薬品工業株式会社 FUSO PHARMACEUTICAL INDUSTRIES, LTD. [JP]/[JP]
Inventors
  • 菊地 晴久 KIKUCHI, Haruhisa
  • 大島 吉輝 OSHIMA, Yoshiteru
  • 服部 俊夫 HATTORI, Toshio
  • 山田 修 YAMADA, Osamu
  • 周 張菁 ZHANG, Jing
  • 喜田 進也 KIDA, Shinya
  • 村瀬 新也 MURASE, Shinya
Agents
  • 山尾 憲人 YAMAO, Norihito
  • 水原 正弘 MIZUHARA, Masahiro
Priority Data
2019-07407709.04.2019JP
Publication Language Japanese (JA)
Filing Language Japanese (JA)
Designated States
Title
(EN) NOVEL COMPOUND HAVING PD-L1 EXPRESSION-SUPPRESSING ACTION
(FR) NOUVEAU COMPOSÉ AYANT UNE ACTION DE SUPPRESSION D'EXPRESSION PD-L1
(JA) PD-L1発現抑制作用を有する新規化合物
Abstract
(EN)
The present invention provides a compound having a PD-L1 expression-suppressing action and an IL-2 production reduction-suppressing action represented by formula (I): [in the formula: R1, R2, m, and n are as defined in the specification.] or a pharmaceutically acceptable salt thereof and a drug useful for treating diseases caused by compromised immune function due to PD-1/PD-L1 binding.
(FR)
La présente invention concerne un composé ayant une action de suppression d'expression de PD-L1 et une action de suppression de réduction de production d'IL-2 représentée par la formule (I) : [dans la formule : R1, R2, m et n sont tels que définis dans la description.] ou un sel pharmaceutiquement acceptable de celui-ci et un médicament utile pour traiter des maladies provoquées par une fonction immunitaire compromise due à la liaison PD-1/PD-L1.
(JA)
本発明は、PD-L1発現抑制作用およびIL-2産生低下抑制作用を有する、式(I): [式中:R、R、mおよびnは、本明細書に定義される通りである。] で表される化合物またはその医薬的に許容される塩およびPD-1/PD-L1結合による免疫能低下に起因する疾患の治療に有用な医薬を提供する。
Latest bibliographic data on file with the International Bureau